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Pentavalent rotavirus vaccine
Pentavalent rotavirus vaccine is a Live attenuated vaccine Biologic drug developed by Sanofi Pasteur, a Sanofi Company. It is currently FDA-approved for Prevention of rotavirus gastroenteritis in infants and young children. Also known as: RotaTeq®.
A live attenuated rotavirus vaccine that stimulates immune response against five rotavirus strains to prevent rotavirus gastroenteritis.
A live attenuated rotavirus vaccine that stimulates immune response against five rotavirus strains to prevent rotavirus gastroenteritis. Used for Prevention of rotavirus gastroenteritis in infants and young children.
At a glance
| Generic name | Pentavalent rotavirus vaccine |
|---|---|
| Also known as | RotaTeq® |
| Sponsor | Sanofi Pasteur, a Sanofi Company |
| Drug class | Live attenuated vaccine |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
The vaccine contains live attenuated (weakened) rotavirus strains representing five common serotypes. When administered orally, it replicates in the intestinal epithelium and induces both humoral and mucosal immune responses, generating antibodies and cellular immunity against rotavirus antigens. This prevents infection and severe disease caused by wild-type rotavirus.
Approved indications
- Prevention of rotavirus gastroenteritis in infants and young children
Common side effects
- Diarrhea
- Vomiting
- Fever
- Irritability
Key clinical trials
- Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants (PHASE1, PHASE2)
- Study of DTwP-HepB-Hib-IPV (SHAN6™) Vaccine Administered Concomitantly With Routine Pediatric Vaccines to Healthy Infants and Toddlers in Thailand (PHASE3)
- Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines (PHASE1)
- Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants (PHASE2)
- PhaseⅡClinical Trial of Oral Hexavalent Reassortant Rotavirus Attenuated Live Vaccine (Vero Cells) (PHASE2)
- Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US (PHASE3)
- Immunogenicity and Safety of Concomitant and Non-Concomitant Administration of RotaTeq® (V260) and Inactivated Poliomyelitis Vaccine in Healthy Chinese Infants (V260-074) (PHASE3)
- Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pentavalent rotavirus vaccine CI brief — competitive landscape report
- Pentavalent rotavirus vaccine updates RSS · CI watch RSS
- Sanofi Pasteur, a Sanofi Company portfolio CI
Frequently asked questions about Pentavalent rotavirus vaccine
What is Pentavalent rotavirus vaccine?
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What is Pentavalent rotavirus vaccine used for?
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Is Pentavalent rotavirus vaccine also known as anything else?
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Related
- Drug class: All Live attenuated vaccine drugs
- Manufacturer: Sanofi Pasteur, a Sanofi Company — full pipeline
- Therapeutic area: All drugs in Immunology / Infectious Disease
- Indication: Drugs for Prevention of rotavirus gastroenteritis in infants and young children
- Also known as: RotaTeq®
- Compare: Pentavalent rotavirus vaccine vs similar drugs
- Pricing: Pentavalent rotavirus vaccine cost, discount & access