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Paracetamol-Tramadol
This combination drug reduces pain through two complementary mechanisms: paracetamol inhibits prostaglandin synthesis in the central nervous system, while tramadol blocks monoamine reuptake and activates opioid receptors.
This combination drug reduces pain through two complementary mechanisms: paracetamol inhibits prostaglandin synthesis in the central nervous system, while tramadol blocks monoamine reuptake and activates opioid receptors. Used for Moderate acute pain, Moderate chronic pain.
At a glance
| Generic name | Paracetamol-Tramadol |
|---|---|
| Also known as | Intravenous Paracetamol and Tramadol |
| Sponsor | Astes |
| Drug class | Analgesic combination (non-opioid + opioid) |
| Target | Cyclooxygenase (COX), opioid receptors (μ, δ, κ), norepinephrine transporter, serotonin transporter |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Paracetamol (acetaminophen) works primarily as a centrally-acting analgesic and antipyretic by inhibiting cyclooxygenase enzymes and reducing prostaglandin production. Tramadol is a synthetic opioid agonist that also inhibits the reuptake of norepinephrine and serotonin, providing additional analgesic effects through multiple pathways. The combination provides synergistic pain relief for moderate pain conditions.
Approved indications
- Moderate acute pain
- Moderate chronic pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Headache
- Somnolence
- Vomiting
Key clinical trials
- Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome (PHASE2)
- The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA (NA)
- Comparison of Postoperative Analgesic Efficacy of Interscalene and Suprascapular Blocks Used in Arthroscopic Shoulder Surgery
- Postoperative Analgesia and Ventilation After Cardiac Surgery
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- QIPB in Inguinal Hernia (NA)
- Efficacy of Modified Thoracoabdominal Nerves Block Through Perichondrial Approach in Total Laparoscopic Hysterectomies (NA)
- Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Paracetamol-Tramadol CI brief — competitive landscape report
- Paracetamol-Tramadol updates RSS · CI watch RSS
- Astes portfolio CI