{"id":"paracetamol-tramadol","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Nausea"},{"rate":"10-15","effect":"Dizziness"},{"rate":"10-15","effect":"Constipation"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Somnolence"},{"rate":"5-10","effect":"Vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) works primarily as a centrally-acting analgesic and antipyretic by inhibiting cyclooxygenase enzymes and reducing prostaglandin production. Tramadol is a synthetic opioid agonist that also inhibits the reuptake of norepinephrine and serotonin, providing additional analgesic effects through multiple pathways. The combination provides synergistic pain relief for moderate pain conditions.","oneSentence":"This combination drug reduces pain through two complementary mechanisms: paracetamol inhibits prostaglandin synthesis in the central nervous system, while tramadol blocks monoamine reuptake and activates opioid receptors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:44.090Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute pain"},{"name":"Moderate chronic pain"}]},"trialDetails":[{"nctId":"NCT06807164","phase":"PHASE2","title":"Serratus Plane Block (SPB) Versus Capsaïcine Versus Botox-A for Chronic Neuropathic Pain in Post-mastectomy Syndrome","status":"RECRUITING","sponsor":"Centre Oscar Lambret","startDate":"2026-03-31","conditions":"Post-Mastectomy Neuropathic Pain Syndrome","enrollment":123},{"nctId":"NCT06112548","phase":"NA","title":"The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following 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