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Oxytocin 4 mIU/mL
Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection.
Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection. Used for Labor induction, Augmentation of labor, Prevention and treatment of postpartum hemorrhage.
At a glance
| Generic name | Oxytocin 4 mIU/mL |
|---|---|
| Sponsor | Assistance Publique - Hôpitaux de Paris |
| Drug class | Oxytocin receptor agonist |
| Target | Oxytocin receptor (OXTR) |
| Modality | Small molecule |
| Therapeutic area | Obstetrics and Gynecology |
| Phase | FDA-approved |
Mechanism of action
Oxytocin is a neurohypophyseal hormone that acts as an agonist at oxytocin receptors, G-protein coupled receptors present on myometrial cells and lactating breast tissue. Receptor activation triggers intracellular calcium mobilization and smooth muscle contraction. In obstetrics, it induces or augments uterine contractions; in lactation, it promotes milk letdown reflex.
Approved indications
- Induction or augmentation of labor
- Management of postpartum hemorrhage
- Promotion of milk letdown in lactation
Common side effects
- Uterine hyperstimulation
- Nausea and vomiting
- Headache
- Hypertension
- Water intoxication (with prolonged high-dose infusion)
Key clinical trials
- Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour (PHASE4)
- Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery (NA)
- Medical Management of Late Intrauterine Death. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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