{"id":"oxytocin-4-miu-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Water intoxication (with prolonged high-dose infusion)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxytocin is a neurohypophyseal hormone that acts as an agonist at oxytocin receptors, G-protein coupled receptors present on myometrial cells and lactating breast tissue. Receptor activation triggers intracellular calcium mobilization and smooth muscle contraction. In obstetrics, it induces or augments uterine contractions; in lactation, it promotes milk letdown reflex.","oneSentence":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:29.335Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction or augmentation of labor"},{"name":"Management of postpartum hemorrhage"},{"name":"Promotion of milk letdown in lactation"}]},"trialDetails":[{"nctId":"NCT04760496","phase":"PHASE4","title":"Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-10-02","conditions":"Obese, Primiparous Women, Oxytocin","enrollment":443},{"nctId":"NCT06333340","phase":"NA","title":"Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery","status":"RECRUITING","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2025-01-14","conditions":"Post Partum Hemorrhage","enrollment":160},{"nctId":"NCT02488642","phase":"PHASE4","title":"Medical Management of Late Intrauterine Death.","status":"COMPLETED","sponsor":"National Institute of Perinatology","startDate":"2008-05","conditions":"Cervical Pregnancy, Maternal Care for Late Fetal Death","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxytocin 4 mIU/mL","genericName":"Oxytocin 4 mIU/mL","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection. Used for Labor induction, Augmentation of labor, Prevention and treatment of postpartum hemorrhage.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}