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Opioid-free Anesthesia-Analgesia Strategy
A multimodal anesthesia-analgesia strategy that avoids opioid medications by combining regional anesthesia, local anesthetics, and non-opioid analgesics.
A multimodal anesthesia-analgesia strategy that avoids opioid medications by combining regional anesthesia, local anesthetics, and non-opioid analgesics to provide perioperative pain control. Used for Perioperative anesthesia and analgesia in surgical patients.
At a glance
| Generic name | Opioid-free Anesthesia-Analgesia Strategy |
|---|---|
| Also known as | Opioid-Free Anesthesia, OFA-A |
| Sponsor | University of Crete |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
This approach uses a combination of techniques including neuraxial blockade, peripheral nerve blocks, local infiltration anesthesia, and non-opioid systemic medications (such as NSAIDs, acetaminophen, ketamine, and dexmedetomidine) to achieve anesthesia and analgesia without relying on opioid drugs. The strategy aims to reduce opioid-related adverse effects including respiratory depression, addiction potential, and postoperative nausea while maintaining effective pain control and anesthetic depth.
Approved indications
- Perioperative anesthesia and analgesia for surgical procedures
Common side effects
- Hypotension
- Bradycardia
- Local anesthetic toxicity
- Nerve injury from regional blocks
Key clinical trials
- Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (NA)
- Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications. (EARLY_PHASE1)
- Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes (NA)
- Effect of Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery (NA)
- Opioid-Free Anesthesia in Cardiac Surgery (PHASE3)
- Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection (NA)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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