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The strategy aims to reduce opioid-related adverse effects including respiratory depression, addiction potential, and postoperative nausea while maintaining effective pain control and anesthetic depth.","oneSentence":"A multimodal anesthesia-analgesia strategy that avoids opioid medications by combining regional anesthesia, local anesthetics, and non-opioid analgesics.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:22.669Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative anesthesia and analgesia for surgical procedures"}]},"trialDetails":[{"nctId":"NCT07264556","phase":"NA","title":"Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-11-01","conditions":"Colorectal Cancer, Opioid-free Anesthesia, NETs","enrollment":90},{"nctId":"NCT06617949","phase":"EARLY_PHASE1","title":"Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.","status":"RECRUITING","sponsor":"Medical College of Wisconsin","startDate":"2025-01-16","conditions":"Substance Use Disorder (SUD)","enrollment":20},{"nctId":"NCT07207304","phase":"NA","title":"Evaluation Of The Influence Of Anesthetic Interventions On The Evolution Of Hepatic Neoplastic Processes","status":"COMPLETED","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2022-02-03","conditions":"Hepato-cellular Carcinoma, Neutrophil Extracellular Trap Formation, Anesthesia","enrollment":153},{"nctId":"NCT06855641","phase":"NA","title":"Effect of Patient Preference for Intraoperative Opioid Use on Early Postoperative Quality of Recovery","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2025-03-24","conditions":"Opioid Analgesia, Quality of Recovery (QoR-15), Outcome Assessment","enrollment":240},{"nctId":"NCT04940689","phase":"PHASE3","title":"Opioid-Free Anesthesia in Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2021-07-22","conditions":"Anesthesia","enrollment":268},{"nctId":"NCT06607029","phase":"NA","title":"Opioid-free Anesthesia Protocol for Neurosurgical Supratentorial Tumor Resection","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2024-10-21","conditions":"Supratentorial Tumors","enrollment":170},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT05752799","phase":"NA","title":"Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids","status":"RECRUITING","sponsor":"G.Gennimatas General Hospital","startDate":"2023-01-01","conditions":"Opioid Use, Unspecified, Bariatric Surgery Candidate","enrollment":70},{"nctId":"NCT05172739","phase":"PHASE4","title":"Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC","status":"RECRUITING","sponsor":"University of Crete","startDate":"2021-10-01","conditions":"Systemic Inflammatory Response Syndrome, Postoperative Pain, Acute, Postoperative Pain, Chronic","enrollment":70},{"nctId":"NCT03347409","phase":"NA","title":"Validation of an ERAS Protocol in Gynecological Surgery","status":"COMPLETED","sponsor":"Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia","startDate":"2017-06-14","conditions":"Surgery, Hysterectomy, Gynecologic Disease","enrollment":166}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Opioid-Free Anesthesia","OFA-A"],"phase":"marketed","status":"active","brandName":"Opioid-free Anesthesia-Analgesia Strategy","genericName":"Opioid-free Anesthesia-Analgesia Strategy","companyName":"University of Crete","companyId":"university-of-crete","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A multimodal anesthesia-analgesia strategy that avoids opioid medications by combining regional anesthesia, local anesthetics, and non-opioid analgesics to provide perioperative pain control. Used for Perioperative anesthesia and analgesia in surgical patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}