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OnabotulinumtoxinA 100 UNT [Botox]

Women and Infants Hospital of Rhode Island · FDA-approved active Small molecule

OnabotulinumtoxinA 100 UNT [Botox] is a Neurotoxin; botulinum toxin type A Small molecule drug developed by Women and Infants Hospital of Rhode Island. It is currently FDA-approved for Cervical dystonia, Blepharospasm, Strabismus. Also known as: Botox, Onabot/A.

OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.

OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.

At a glance

Generic nameOnabotulinumtoxinA 100 UNT [Botox]
Also known asBotox, Onabot/A
SponsorWomen and Infants Hospital of Rhode Island
Drug classNeurotoxin; botulinum toxin type A
TargetSNAP-25 (synaptosome-associated protein of 25 kDa)
ModalitySmall molecule
Therapeutic areaNeurology; Dermatology; Aesthetics
PhaseFDA-approved

Mechanism of action

The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle release. This prevents neurotransmitter signaling at the neuromuscular junction, resulting in flaccid paralysis of targeted muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.

Approved indications

Common side effects

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Frequently asked questions about OnabotulinumtoxinA 100 UNT [Botox]

What is OnabotulinumtoxinA 100 UNT [Botox]?

OnabotulinumtoxinA 100 UNT [Botox] is a Neurotoxin; botulinum toxin type A drug developed by Women and Infants Hospital of Rhode Island, indicated for Cervical dystonia, Blepharospasm, Strabismus.

How does OnabotulinumtoxinA 100 UNT [Botox] work?

OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.

What is OnabotulinumtoxinA 100 UNT [Botox] used for?

OnabotulinumtoxinA 100 UNT [Botox] is indicated for Cervical dystonia, Blepharospasm, Strabismus, Chronic migraine, Severe primary axillary hyperhidrosis.

Who makes OnabotulinumtoxinA 100 UNT [Botox]?

OnabotulinumtoxinA 100 UNT [Botox] is developed and marketed by Women and Infants Hospital of Rhode Island (see full Women and Infants Hospital of Rhode Island pipeline at /company/women-and-infants-hospital-of-rhode-island).

Is OnabotulinumtoxinA 100 UNT [Botox] also known as anything else?

OnabotulinumtoxinA 100 UNT [Botox] is also known as Botox, Onabot/A.

What drug class is OnabotulinumtoxinA 100 UNT [Botox] in?

OnabotulinumtoxinA 100 UNT [Botox] belongs to the Neurotoxin; botulinum toxin type A class. See all Neurotoxin; botulinum toxin type A drugs at /class/neurotoxin-botulinum-toxin-type-a.

What development phase is OnabotulinumtoxinA 100 UNT [Botox] in?

OnabotulinumtoxinA 100 UNT [Botox] is FDA-approved (marketed).

What are the side effects of OnabotulinumtoxinA 100 UNT [Botox]?

Common side effects of OnabotulinumtoxinA 100 UNT [Botox] include Headache, Neck pain, Injection site pain, Muscle weakness, Eyelid ptosis, Diplopia.

What does OnabotulinumtoxinA 100 UNT [Botox] target?

OnabotulinumtoxinA 100 UNT [Botox] targets SNAP-25 (synaptosome-associated protein of 25 kDa) and is a Neurotoxin; botulinum toxin type A.

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