{"id":"onabotulinumtoxina-100-unt-botox","safety":{"commonSideEffects":[{"rate":"13","effect":"Headache"},{"rate":"8","effect":"Neck pain"},{"rate":"5","effect":"Injection site pain"},{"rate":"5","effect":"Muscle weakness"},{"rate":"1–3","effect":"Eyelid ptosis"},{"rate":"1–2","effect":"Diplopia"},{"rate":"1","effect":"Flu-like syndrome"}]},"_chembl":{"chemblId":"CHEMBL1201574","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug is a botulinum toxin serotype A that irreversibly cleaves SNAP-25, a protein essential for acetylcholine vesicle release. This prevents neurotransmitter signaling at the neuromuscular junction, resulting in flaccid paralysis of targeted muscles. The effect is temporary, lasting 3–4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:58:18.816Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Strabismus"},{"name":"Chronic migraine"},{"name":"Severe primary axillary hyperhidrosis"},{"name":"Glabellar lines (aesthetic)"},{"name":"Crow's feet (aesthetic)"},{"name":"Forehead lines (aesthetic)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Botox","Onabot/A"],"phase":"marketed","status":"active","brandName":"OnabotulinumtoxinA 100 UNT [Botox]","genericName":"OnabotulinumtoxinA 100 UNT [Botox]","companyName":"Women and Infants Hospital of Rhode Island","companyId":"women-and-infants-hospital-of-rhode-island","modality":"Small molecule","firstApprovalDate":"","aiSummary":"OnabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis. Used for Cervical dystonia, Blepharospasm, Strabismus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}