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Normal Saline added intrathecally
Normal saline administered intrathecally provides isotonic fluid replacement and maintains cerebrospinal fluid (CSF) volume and osmolarity in the spinal canal.
Normal saline administered intrathecally provides isotonic fluid replacement and maintains cerebrospinal fluid (CSF) volume and osmolarity in the spinal canal. Used for Intrathecal fluid replacement and CSF volume maintenance (supportive care).
At a glance
| Generic name | Normal Saline added intrathecally |
|---|---|
| Also known as | N/S |
| Sponsor | KAT General Hospital |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | FDA-approved |
Mechanism of action
Intrathecal normal saline is a supportive therapy that delivers 0.9% sodium chloride solution directly into the subarachnoid space. It serves to maintain CSF homeostasis, replace lost or depleted fluid, and preserve proper osmotic balance within the central nervous system. This is a non-pharmacological intervention used primarily for symptomatic relief and supportive care rather than a drug with a specific molecular mechanism of action.
Approved indications
- Intrathecal fluid replacement and CSF volume maintenance (supportive care)
Common side effects
- Headache
- Back pain
- Infection/meningitis (procedure-related)
- Spinal cord injury (procedure-related)
Key clinical trials
- Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor (PHASE4)
- Intrathecal Fentanyl and Dexmedetomidine Added to Bupivacaine for Subarachnoid Anaesthesia for Percutaneous Nephrolithotomy (NA)
- Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery (PHASE4)
- Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery (PHASE4)
- Enhanced Recovery After Urologic Surgery (NA)
- Intrathecal Dexmedetomidine Versus Transversus Abdominus Plane Block (TAP) for Postoperative Analgesia After Cesarean Section. (NA)
- Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries (NA)
- Dexmetomidine Intrathecally and Intravenously Additionally to Spinal Anaesthesia, in Total Knee Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Normal Saline added intrathecally CI brief — competitive landscape report
- Normal Saline added intrathecally updates RSS · CI watch RSS
- KAT General Hospital portfolio CI