{"id":"normal-saline-added-intrathecally","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Back pain"},{"rate":null,"effect":"Infection/meningitis (procedure-related)"},{"rate":null,"effect":"Spinal cord injury (procedure-related)"}]},"_chembl":{"chemblId":"CHEMBL2108783","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intrathecal normal saline is a supportive therapy that delivers 0.9% sodium chloride solution directly into the subarachnoid space. It serves to maintain CSF homeostasis, replace lost or depleted fluid, and preserve proper osmotic balance within the central nervous system. This is a non-pharmacological intervention used primarily for symptomatic relief and supportive care rather than a drug with a specific molecular mechanism of action.","oneSentence":"Normal saline administered intrathecally provides isotonic fluid replacement and maintains cerebrospinal fluid (CSF) volume and osmolarity in the spinal canal.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:57:40.664Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intrathecal fluid replacement and CSF volume maintenance (supportive care)"}]},"trialDetails":[{"nctId":"NCT06823349","phase":"PHASE4","title":"Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor","status":"RECRUITING","sponsor":"Jehan George Sadek","startDate":"2025-02-01","conditions":"Vaginal Delivery, Normal Labor","enrollment":90},{"nctId":"NCT06957301","phase":"NA","title":"Intrathecal Fentanyl and Dexmedetomidine Added to Bupivacaine for Subarachnoid Anaesthesia for Percutaneous Nephrolithotomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Alexandria University","startDate":"2025-04-10","conditions":"Percutaneous Nephrolithotomy (PCNL)","enrollment":100},{"nctId":"NCT06935708","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery","status":"RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-04-08","conditions":"Colorectal Carcinoma, Analgesia, Postoperative, Laparotomy","enrollment":98},{"nctId":"NCT06881563","phase":"PHASE4","title":"Intrathecal Morphine Versus Epidural Analgesia for Laparoscopic Colon Surgery","status":"NOT_YET_RECRUITING","sponsor":"Meri Mirceta","startDate":"2025-03","conditions":"Postoperative Pain, Analgesia, Colorectal Cancer","enrollment":98},{"nctId":"NCT06789744","phase":"NA","title":"Enhanced Recovery After Urologic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Xiaguang Duan","startDate":"2025-02-01","conditions":"Circumcision, Hydrocelectomy, Hernia","enrollment":150},{"nctId":"NCT04969705","phase":"NA","title":"Intrathecal Dexmedetomidine Versus Transversus Abdominus Plane Block (TAP) for Postoperative Analgesia After Cesarean Section.","status":"COMPLETED","sponsor":"Sohag University","startDate":"2022-01-01","conditions":"Pain Management in Adult Females in Child Bearing Period Aging From 20 to 45 Years Who Are Scheduled for Elective Cesarean Section","enrollment":60},{"nctId":"NCT04779060","phase":"NA","title":"Intrathecal Fentanyle Versus Dexamethasone in Gynacological Laparoscopic Surgeries","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-07","conditions":"Intraoperativ Pain","enrollment":120},{"nctId":"NCT02966249","phase":"PHASE4","title":"Dexmetomidine Intrathecally and Intravenously Additionally to Spinal Anaesthesia, in Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"KAT General Hospital","startDate":"2016-10","conditions":"Neuromuscular Block","enrollment":90},{"nctId":"NCT02731430","phase":"PHASE2, PHASE3","title":"Intrathecal Morphine for Postoperative Analgesia Following Laparoscopic Bariatric Surgery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2015-12","conditions":"Postoperative Pain","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["N/S"],"phase":"marketed","status":"active","brandName":"Normal Saline added intrathecally","genericName":"Normal Saline added intrathecally","companyName":"KAT General Hospital","companyId":"kat-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Normal saline administered intrathecally provides isotonic fluid replacement and maintains cerebrospinal fluid (CSF) volume and osmolarity in the spinal canal. Used for Intrathecal fluid replacement and CSF volume maintenance (supportive care).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}