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Normal dose of alfentanil hydrochloride
Normal dose of alfentanil hydrochloride is a Synthetic opioid agonist Small molecule drug developed by University Hospital, Ghent. It is currently FDA-approved for Analgesia and sedation during general anesthesia, Acute postoperative pain management, Sedation in intensive care settings.
Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.
Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Intraoperative analgesia and sedation during general anesthesia, Analgesia and sedation for short procedures and diagnostic interventions, Postoperative analgesia.
At a glance
| Generic name | Normal dose of alfentanil hydrochloride |
|---|---|
| Sponsor | University Hospital, Ghent |
| Drug class | Synthetic opioid agonist |
| Target | Mu opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Alfentanil acts as a selective agonist at mu opioid receptors, which are distributed throughout the brain and spinal cord. This binding modulates pain perception and produces sedative effects. It is a rapid-onset, short-acting opioid commonly used in perioperative settings due to its quick onset and offset kinetics.
Approved indications
- Analgesia and sedation during general anesthesia
- Acute postoperative pain management
- Sedation in intensive care settings
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Muscle rigidity
- Dizziness
Key clinical trials
- Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols (PHASE4)
- Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy (PHASE4)
- Intubation Time With Low Dose Rocuronium (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Normal dose of alfentanil hydrochloride CI brief — competitive landscape report
- Normal dose of alfentanil hydrochloride updates RSS · CI watch RSS
- University Hospital, Ghent portfolio CI
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Related
- Drug class: All Synthetic opioid agonist drugs
- Target: All drugs targeting Mu opioid receptor (μ-OR)
- Manufacturer: University Hospital, Ghent — full pipeline
- Therapeutic area: All drugs in Anesthesia and Pain Management
- Indication: Drugs for Analgesia and sedation during general anesthesia
- Indication: Drugs for Acute postoperative pain management
- Indication: Drugs for Sedation in intensive care settings
- Compare: Normal dose of alfentanil hydrochloride vs similar drugs
- Pricing: Normal dose of alfentanil hydrochloride cost, discount & access