{"id":"normal-dose-of-alfentanil-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Muscle rigidity"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Alfentanil acts as a selective agonist at mu opioid receptors, which are distributed throughout the brain and spinal cord. This binding modulates pain perception and produces sedative effects. It is a rapid-onset, short-acting opioid commonly used in perioperative settings due to its quick onset and offset kinetics.","oneSentence":"Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:35:07.667Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Analgesia and sedation during general anesthesia"},{"name":"Acute postoperative pain management"},{"name":"Sedation in intensive care settings"}]},"trialDetails":[{"nctId":"NCT00742807","phase":"PHASE4","title":"Pain Evaluation During Follicle Aspiration: Comparison of Two Sedation Protocols","status":"WITHDRAWN","sponsor":"University Hospital, Ghent","startDate":"2008-08","conditions":"Pain","enrollment":""},{"nctId":"NCT01470170","phase":"PHASE4","title":"Regimen of Alfentanil in Propofol Sedative Fibro-bronchoscopy","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2010-10","conditions":"Hypoxemia","enrollment":173},{"nctId":"NCT01464489","phase":"NA","title":"Intubation Time With Low Dose Rocuronium","status":"COMPLETED","sponsor":"Gachon University Gil Medical Center","startDate":"2011-05","conditions":"Intubation; Difficult","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Normal dose of alfentanil hydrochloride","genericName":"Normal dose of alfentanil hydrochloride","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce rapid analgesia and sedation. Used for Intraoperative analgesia and sedation during general anesthesia, Analgesia and sedation for short procedures and diagnostic interventions, Postoperative analgesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}