Last reviewed · How we verify

Migranal nasal spray at 4 hour

Thomas Jefferson University · FDA-approved active Small molecule

Migranal nasal spray at 4 hour is a Ergot alkaloid; 5-HT1B/1D receptor agonist Small molecule drug developed by Thomas Jefferson University. It is currently FDA-approved for Acute migraine headache with or without aura. Also known as: Dihydroergotamine (DHE).

Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways.

Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways. Used for Acute migraine headache with or without aura.

At a glance

Generic nameMigranal nasal spray at 4 hour
Also known asDihydroergotamine (DHE)
SponsorThomas Jefferson University
Drug classErgot alkaloid; 5-HT1B/1D receptor agonist
Target5-HT1B receptor, 5-HT1D receptor
ModalitySmall molecule
Therapeutic areaNeurology
PhaseFDA-approved

Mechanism of action

Dihydroergotamine is an ergot alkaloid derivative that binds to serotonin receptors (5-HT1B and 5-HT1D) on cranial blood vessels and nerve terminals. This causes vasoconstriction of dilated cerebral blood vessels and reduces the release of pro-inflammatory neuropeptides involved in migraine pain transmission. The nasal spray formulation provides rapid systemic absorption for acute migraine relief.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Migranal nasal spray at 4 hour

What is Migranal nasal spray at 4 hour?

Migranal nasal spray at 4 hour is a Ergot alkaloid; 5-HT1B/1D receptor agonist drug developed by Thomas Jefferson University, indicated for Acute migraine headache with or without aura.

How does Migranal nasal spray at 4 hour work?

Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways.

What is Migranal nasal spray at 4 hour used for?

Migranal nasal spray at 4 hour is indicated for Acute migraine headache with or without aura.

Who makes Migranal nasal spray at 4 hour?

Migranal nasal spray at 4 hour is developed and marketed by Thomas Jefferson University (see full Thomas Jefferson University pipeline at /company/thomas-jefferson-university).

Is Migranal nasal spray at 4 hour also known as anything else?

Migranal nasal spray at 4 hour is also known as Dihydroergotamine (DHE).

What drug class is Migranal nasal spray at 4 hour in?

Migranal nasal spray at 4 hour belongs to the Ergot alkaloid; 5-HT1B/1D receptor agonist class. See all Ergot alkaloid; 5-HT1B/1D receptor agonist drugs at /class/ergot-alkaloid-5-ht1b-1d-receptor-agonist.

What development phase is Migranal nasal spray at 4 hour in?

Migranal nasal spray at 4 hour is FDA-approved (marketed).

What are the side effects of Migranal nasal spray at 4 hour?

Common side effects of Migranal nasal spray at 4 hour include Nasal congestion or rhinitis, Dizziness or vertigo, Nausea, Taste disturbance, Somnolence.

What does Migranal nasal spray at 4 hour target?

Migranal nasal spray at 4 hour targets 5-HT1B receptor, 5-HT1D receptor and is a Ergot alkaloid; 5-HT1B/1D receptor agonist.

Related