Who are Migranal nasal spray at 4 hour's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): naratriptan HCl, Sumatriptan Succinate Oral Tablet, Migranal nasal spray at 1 hour, sumatriptan succinate/naproxen sodium, Comparator: sumatriptan, Placebo to rizatriptan tablets.

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Last reviewed 2026-05-17 · How we verify

Migranal nasal spray at 4 hour — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Migranal nasal spray at 4 hour (Migranal nasal spray at 4 hour) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Ergot alkaloid; 5-HT1B/1D receptor agonist. Area: Neurology.

marketed Ergot alkaloid; 5-HT1B/1D receptor agonist 5-HT1B receptor, 5-HT1D receptor Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Migranal nasal spray at 4 hour (Migranal nasal spray at 4 hour) — Thomas Jefferson University. Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Migranal nasal spray at 4 hour TARGET	Migranal nasal spray at 4 hour	Thomas Jefferson University	marketed	Ergot alkaloid; 5-HT1B/1D receptor agonist	5-HT1B receptor, 5-HT1D receptor
naratriptan HCl	naratriptan HCl	Cady, Roger, M.D.	marketed	Triptan (5-HT1B/1D receptor agonist)	5-HT1B receptor, 5-HT1D receptor
Sumatriptan Succinate Oral Tablet	Sumatriptan Succinate Oral Tablet	Damanhour Teaching Hospital	marketed	Triptan (5-HT1B/1D receptor agonist)	5-HT1B receptor, 5-HT1D receptor
Migranal nasal spray at 1 hour	Migranal nasal spray at 1 hour	Thomas Jefferson University	marketed	Ergot alkaloid; serotonin receptor agonist	5-HT1B receptor, 5-HT1D receptor
sumatriptan succinate/naproxen sodium	sumatriptan succinate/naproxen sodium	GlaxoSmithKline	marketed	5-HT1B/1D receptor agonist combined with NSAID	5-HT1B receptor, 5-HT1D receptor, COX-1, COX-2
Comparator: sumatriptan	Comparator: sumatriptan	Organon and Co	phase 3	Triptan (5-HT1B/1D receptor agonist)	5-HT1B receptor, 5-HT1D receptor
Placebo to rizatriptan tablets	Placebo to rizatriptan tablets	Merck Sharp & Dohme LLC	phase 3	Triptan (5-HT1B/1D receptor agonist)	5-HT1B receptor, 5-HT1D receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Ergot alkaloid; 5-HT1B/1D receptor agonist class)

Thomas Jefferson University · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Migranal nasal spray at 4 hour — Competitive Intelligence Brief. https://druglandscape.com/ci/migranal-nasal-spray-at-4-hour. Accessed 2026-05-17.

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