{"id":"migranal-nasal-spray-at-4-hour","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal congestion or rhinitis"},{"rate":null,"effect":"Dizziness or vertigo"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Taste disturbance"},{"rate":null,"effect":"Somnolence"}]},"_chembl":{"chemblId":"CHEMBL4303347","moleculeType":"Small molecule","molecularWeight":"455.60"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dihydroergotamine is an ergot alkaloid derivative that binds to serotonin receptors (5-HT1B and 5-HT1D) on cranial blood vessels and nerve terminals. This causes vasoconstriction of dilated cerebral blood vessels and reduces the release of pro-inflammatory neuropeptides involved in migraine pain transmission. The nasal spray formulation provides rapid systemic absorption for acute migraine relief.","oneSentence":"Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:55:18.128Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute migraine headache with or without aura"}]},"trialDetails":[{"nctId":"NCT00335777","phase":"PHASE4","title":"A Research Study Examining Migranal and Skin Sensitivity in Subjects With Migraine","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2006-08","conditions":"Migraine","enrollment":64}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dihydroergotamine (DHE)"],"phase":"marketed","status":"active","brandName":"Migranal nasal spray at 4 hour","genericName":"Migranal nasal spray at 4 hour","companyName":"Thomas Jefferson University","companyId":"thomas-jefferson-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dihydroergotamine acts as a vasoconstrictor and 5-HT1B/1D receptor agonist to relieve migraine headaches by narrowing blood vessels around the brain and inhibiting pain pathways. Used for Acute migraine headache with or without aura.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}