Midodrine Oral Tablet

Institute of Liver and Biliary Sciences, India · FDA-approved active Small molecule

Midodrine Oral Tablet is a Alpha-1 adrenergic agonist Small molecule drug developed by Institute of Liver and Biliary Sciences, India. It is currently FDA-approved for Orthostatic hypotension, Symptomatic hypotension. Also known as: ProAmatine®, Midodrine pill, ProAmatine, Midodrine hydrochloride.

Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels.

Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels. Used for Orthostatic hypotension, Symptomatic hypotension.

At a glance

Generic name	Midodrine Oral Tablet
Also known as	ProAmatine®, Midodrine pill, ProAmatine, Midodrine hydrochloride
Sponsor	Institute of Liver and Biliary Sciences, India
Drug class	Alpha-1 adrenergic agonist
Target	Alpha-1 adrenergic receptor
Modality	Small molecule
Therapeutic area	Cardiovascular
Phase	FDA-approved

Mechanism of action

Midodrine is a prodrug that is metabolized to desglymidodrine, its active metabolite, which selectively stimulates alpha-1 adrenergic receptors on arterioles and venules. This peripheral vasoconstriction increases both systolic and diastolic blood pressure, making it useful for treating conditions characterized by abnormally low blood pressure. The drug does not cross the blood-brain barrier significantly, limiting central nervous system effects.

Approved indications

• Orthostatic hypotension
• Symptomatic hypotension

Common side effects

• Hypertension
• Piloerection (goosebumps)
• Pruritus
• Headache
• Urinary retention

Key clinical trials

• Midodrine Effect on the Mortality Rates in Septic Shock Patients (PHASE2)
• Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension (PHASE2, PHASE3)
• Treatment Strategy of Vasovagal Syncope (NA)
• Preoperative Oral Midodrine Versus Intraoperative Intravenous Norepinephrine in Preventing Post-spinal Anesthesia Hypotension in Cesarean Section: A Prospective Double-blind Randomized Clinical Trial (NA)
• To Assess the Efficacy of Midodrine in Prevention of Cirrhosis Related Complications in Children Awaiting Liver Transplantation. (NA)
• Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population (NA)
• Midodrine is Effective in Management of Intradialytic Hypotension Among Critically-ill Patients With Acute Kidney Injury (NA)
• Midodrine Versus Albumin for Prevention of Paracentesis Induced Circulatory Disturbance (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Midodrine Oral Tablet CI brief — competitive landscape report
• Midodrine Oral Tablet updates RSS · CI watch RSS
• Institute of Liver and Biliary Sciences, India portfolio CI

Frequently asked questions about Midodrine Oral Tablet

What is Midodrine Oral Tablet?

Midodrine Oral Tablet is a Alpha-1 adrenergic agonist drug developed by Institute of Liver and Biliary Sciences, India, indicated for Orthostatic hypotension, Symptomatic hypotension.

How does Midodrine Oral Tablet work?

Midodrine is an alpha-1 adrenergic agonist that increases blood pressure by constricting blood vessels.

What is Midodrine Oral Tablet used for?

Midodrine Oral Tablet is indicated for Orthostatic hypotension, Symptomatic hypotension.

Who makes Midodrine Oral Tablet?

Midodrine Oral Tablet is developed and marketed by Institute of Liver and Biliary Sciences, India (see full Institute of Liver and Biliary Sciences, India pipeline at /company/institute-of-liver-and-biliary-sciences-india).

Is Midodrine Oral Tablet also known as anything else?

Midodrine Oral Tablet is also known as ProAmatine®, Midodrine pill, ProAmatine, Midodrine hydrochloride.

What drug class is Midodrine Oral Tablet in?

Midodrine Oral Tablet belongs to the Alpha-1 adrenergic agonist class. See all Alpha-1 adrenergic agonist drugs at /class/alpha-1-adrenergic-agonist.

What development phase is Midodrine Oral Tablet in?

Midodrine Oral Tablet is FDA-approved (marketed).

What are the side effects of Midodrine Oral Tablet?

Common side effects of Midodrine Oral Tablet include Hypertension, Piloerection (goosebumps), Pruritus, Headache, Urinary retention.

What does Midodrine Oral Tablet target?

Midodrine Oral Tablet targets Alpha-1 adrenergic receptor and is a Alpha-1 adrenergic agonist.

Related

• Drug class: All Alpha-1 adrenergic agonist drugs
• Target: All drugs targeting Alpha-1 adrenergic receptor
• Manufacturer: Institute of Liver and Biliary Sciences, India — full pipeline
• Therapeutic area: All drugs in Cardiovascular
• Indication: Drugs for Orthostatic hypotension
• Indication: Drugs for Symptomatic hypotension
• Also known as: ProAmatine®, Midodrine pill, ProAmatine, Midodrine hydrochloride