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midazolam,fentanyl,etomidate,Cisatracurium besylate
This is a combination of four anesthetic and neuromuscular blocking agents used together for induction and maintenance of general anesthesia with paralysis.
This is a combination of four anesthetic and neuromuscular blocking agents used together for induction and maintenance of general anesthesia with paralysis. Used for Induction and maintenance of general anesthesia, Neuromuscular blockade during surgical procedures.
At a glance
| Generic name | midazolam,fentanyl,etomidate,Cisatracurium besylate |
|---|---|
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University |
| Drug class | Anesthetic combination (benzodiazepine, opioid, hypnotic, neuromuscular blocker) |
| Target | GABA-A receptor (midazolam, etomidate), mu opioid receptor (fentanyl), nicotinic acetylcholine receptor at neuromuscular junction (cisatracurium) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Midazolam is a benzodiazepine that enhances GABA-A receptor signaling for sedation; fentanyl is an opioid mu-receptor agonist for analgesia and sedation; etomidate is a non-barbiturate hypnotic that modulates GABA-A receptors for rapid induction; and cisatracurium besylate is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at the neuromuscular junction to produce paralysis.
Approved indications
- Induction and maintenance of general anesthesia
- Neuromuscular blockade during surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Histamine release (cisatracurium)
- Prolonged paralysis
Key clinical trials
- Standardised Drug Provocation Testing in Perioperative Hypersensitivity (NA)
- Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus (PHASE4)
- Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia (PHASE4)
- Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients (PHASE4)
- Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients (PHASE4)
- Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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