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Bispectral Index Guiding Etomidate Used in Children Aged 3 to 10 for Clinical Anesthesia Induction
This research through using bispectral index to guide the induced dose and speed of etomidate lipid emulsion for pediatric total venous anesthesia,and to provide a reference for clinical anesthesia physician.
Details
| Lead sponsor | Henan Provincial People's Hospital |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 120 |
| Start date | 2014-10 |
Conditions
- Bispectral Index
- Pediatric
- Etomidate
- Induction
Interventions
- etomidate
- propofol
- sevoflurane
Primary outcomes
- the amount of drugs — from the beginning of induction to Bispectral Index < 50,up to 5 minutes
the amount of etomidate,propofol and sevoflurane used in anesthesia induction - the drugs used time — from the beginning of induction to Bispectral Index < 50,expected to be within 1 minute
the injection time of etomidate and propofol, and the inhale time of sevoflurane during anesthesia induction - numbers of muscular fibrillation — from the beginning of induction to Bispectral Index < 50,up to 5 minutes
numbers of muscular fibrillation in anesthesia induction - degree of inflammation reaction — baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation
serum levels of interleukin 6 and tumor necrosis factor α will be measured at each time point using ELISA method - adrenal function — baseline,5 minutes after indution,5 minutes before operation end,30 mimutes、24h and 48h after operation
serum level of cortisol will be measured at each time point using radioimmunoassay