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Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients-A Single Center,Randomized, Double-blinded,Controlled Study
The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients
Details
| Lead sponsor | First Affiliated Hospital Xi'an Jiaotong University |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 90 |
| Start date | 2014-09 |
| Completion | 2015-09 |
Conditions
- Postoperative Cognitive Dysfunction
Interventions
- dexmedetomidine
- dexmedetomidine
- normal saline
- midazolam,fentanyl,etomidate,Cisatracurium besylate
- cisatracurium besylate,propofol,remifentanil,sevoflurane
Primary outcomes
- Change from baseline to postoperation in cognitive function — One day before operation,third day after operation,sixth day after operaion
Mini-mental State Examination - Change from baseline to postoperation in recent memory — One day before operation,third day after operation,sixth day after operation
Rey Auditory Verbal Learning Test - Change from baseline to postoperation in visual space and directional force — One day before operation,third day after operation,sixth day after operaion
Trail Making Test A,Trail Making Test B - Change from baseline to postoperation in attention — One day before operation,third day after operation,sixth day after operaion
Digit Span Test - Change from baseline to postoperation in pain scores — One day before operation,third day after operation,sixth day after operation
Visual analog scales - Change from baseline to postoperation in depression scale — One day before operation,third day after operation,sixth day after operation
Beck Depression Inventory