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Metamizole and Ibuprofen
Metamizole and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing pain, inflammation, and fever.
This is a fixed-dose combination of two nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) enzymes to reduce pain, inflammation, and fever. Used for Acute pain management, Postoperative pain.
At a glance
| Generic name | Metamizole and Ibuprofen |
|---|---|
| Sponsor | University Hospital, Basel, Switzerland |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) combination |
| Target | Cyclooxygenase (COX-1 and COX-2) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Rheumatology |
| Phase | FDA-approved |
Mechanism of action
Metamizole (dipyrone) is a pyrazolone NSAID that inhibits COX-1 and COX-2 enzymes, reducing prostaglandin production and providing analgesic and antipyretic effects. Ibuprofen is a propionic acid NSAID with similar COX inhibition. This combination leverages both agents' anti-inflammatory and analgesic properties for enhanced pain relief.
Approved indications
- Acute pain and fever
- Inflammatory conditions
Common side effects
- Gastrointestinal upset (nausea, dyspepsia)
- Gastrointestinal bleeding
- Renal impairment
- Agranulocytosis (metamizole-specific risk)
- Allergic reactions
Key clinical trials
- Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children (PHASE4)
- Treatment of Pelvic Ring Fractures in the Elderly (NA)
- Efficacy of Metamizole Versus Ibuprofen and a Short Educational Intervention Versus Standard Care in Acute Low Back Pain (PHASE4)
- Study of Postoperative ICC Analgesia (PHASE3)
- Delirium in Elderly Patients With Trauma of the Hip (PHASE4)
- Ultrasound-guided Block of the Supraclavicular Nerves in Clavicular Fractures (NA)
- Evaluation of the Added Value of Metamizole to Standard Post-operative Treatment After Ambulant Surgery (NA)
- Migraine Abortive Treatment
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metamizole and Ibuprofen CI brief — competitive landscape report
- Metamizole and Ibuprofen updates RSS · CI watch RSS
- University Hospital, Basel, Switzerland portfolio CI