{"id":"metamizole-and-ibuprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, dyspepsia)"},{"rate":null,"effect":"Gastrointestinal bleeding"},{"rate":null,"effect":"Renal impairment"},{"rate":null,"effect":"Agranulocytosis (metamizole-specific risk)"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL461522","moleculeType":"Small molecule","molecularWeight":"311.36"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metamizole (dipyrone) is a pyrazolone NSAID that inhibits COX-1 and COX-2 enzymes, reducing prostaglandin production and providing analgesic and antipyretic effects. Ibuprofen is a propionic acid NSAID with similar COX inhibition. This combination leverages both agents' anti-inflammatory and analgesic properties for enhanced pain relief.","oneSentence":"Metamizole and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing pain, inflammation, and fever.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:21.505Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain and fever"},{"name":"Inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT07024199","phase":"PHASE4","title":"Comparison of the Effectiveness of Paracetamol With Ibuprofen or Paracetamol With Metamizole in Treating Pain in Acute Pancreatitis in Children","status":"RECRUITING","sponsor":"Medical University of Warsaw","startDate":"2025-09","conditions":"Pancreatitis, Acute, Pain, Acute, Pancreatic Disease","enrollment":78},{"nctId":"NCT02590783","phase":"NA","title":"Treatment of Pelvic Ring Fractures in the Elderly","status":"TERMINATED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2017-10-17","conditions":"Pelvic Pain","enrollment":88},{"nctId":"NCT04111315","phase":"PHASE4","title":"Efficacy of Metamizole Versus Ibuprofen and a Short Educational Intervention Versus Standard Care in Acute Low Back Pain","status":"UNKNOWN","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2019-12-15","conditions":"Low Back Pain","enrollment":120},{"nctId":"NCT04939545","phase":"PHASE3","title":"Study of Postoperative ICC Analgesia","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2021-12-15","conditions":"Postoperative Analgesia","enrollment":32},{"nctId":"NCT02689024","phase":"PHASE4","title":"Delirium in Elderly Patients With Trauma of the Hip","status":"TERMINATED","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2016-05","conditions":"Hip Fractures, Anesthesia","enrollment":239},{"nctId":"NCT04685291","phase":"NA","title":"Ultrasound-guided Block of the Supraclavicular Nerves in Clavicular Fractures","status":"COMPLETED","sponsor":"Eckehart SCHÖLL","startDate":"2021-04-15","conditions":"Clavicular Fracture, Pain, Acute","enrollment":42},{"nctId":"NCT04082728","phase":"NA","title":"Evaluation of the Added Value of Metamizole to Standard Post-operative Treatment After Ambulant Surgery","status":"COMPLETED","sponsor":"Jessa Hospital","startDate":"2019-11-28","conditions":"Analgesia, Surgery, Recovery","enrollment":110},{"nctId":"NCT05048914","phase":"","title":"Migraine Abortive Treatment","status":"UNKNOWN","sponsor":"Bnai Zion Medical Center","startDate":"2019-09-03","conditions":"Migraine Disorders","enrollment":50},{"nctId":"NCT02686021","phase":"PHASE4","title":"Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2016-02-15","conditions":"Pain, Postoperative","enrollment":36},{"nctId":"NCT03622489","phase":"PHASE4","title":"Comparing Protocols for Analgesia Following Elective Cesarean Section","status":"UNKNOWN","sponsor":"Wolfson Medical Center","startDate":"2017-03-01","conditions":"Postoperative Pain, Post-Cesarean Section","enrollment":120},{"nctId":"NCT01359020","phase":"PHASE4","title":"Ibuprofen, Acetaminophen and Dipyrone to Fever Control in Children","status":"COMPLETED","sponsor":"Mantecorp Industria Quimica e Farmaceutica Ltd.","startDate":"2007-01","conditions":"Fever","enrollment":396},{"nctId":"NCT00763997","phase":"NA","title":"Study of the Effect of Dipyrone, Ibuprofen, Paracetamol and Parecoxib on the Platelet Aggregation in Analgetic Dosages","status":"COMPLETED","sponsor":"Ruhr University of Bochum","startDate":"2004-02","conditions":"Platelet Aggregation","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":34,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Metamizole and Ibuprofen","genericName":"Metamizole and Ibuprofen","companyName":"University Hospital, Basel, Switzerland","companyId":"university-hospital-basel-switzerland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a fixed-dose combination of two nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase (COX) enzymes to reduce pain, inflammation, and fever. Used for Acute pain management, Postoperative pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}