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Melatonin Patches
Melatonin Patches is a Melatonin receptor agonist Small molecule drug developed by Ain Shams University. It is currently FDA-approved for Insomnia and sleep disorders, Circadian rhythm sleep-wake disorders. Also known as: Melatonin Stickers.
Melatonin binds to melatonin receptors (MT1 and MT2) to regulate circadian rhythm and promote sleep.
Melatonin patches are a type of transdermal therapeutic system that contain 2.1 mg of melatonin, a small molecule that acts as a melatonin receptor agonist. These patches have been studied for various conditions, including urological surgery, postoperative pain relief, dental anxiety, and cranial nerve diseases, typically applied to the upper chest or forearm before sleep.
At a glance
| Generic name | Melatonin Patches |
|---|---|
| Also known as | Melatonin Stickers |
| Sponsor | Ain Shams University |
| Drug class | Melatonin receptor agonist |
| Target | MT1 and MT2 melatonin receptors |
| Modality | Small molecule |
| Therapeutic area | Neurology / Sleep Medicine |
| Phase | FDA-approved |
Mechanism of action
Melatonin is an endogenous hormone that acts as a chronobiotic agent, synchronizing the body's internal clock with the external light-dark cycle. By activating melatonin receptors in the suprachiasmatic nucleus and other tissues, it facilitates sleep onset and maintains sleep-wake cycle homeostasis. The transdermal patch formulation provides sustained delivery to maintain therapeutic melatonin levels throughout the night.
Approved indications
- Insomnia and sleep disorders
- Circadian rhythm sleep-wake disorders
Common side effects
- Headache
- Dizziness
- Skin irritation at patch site
- Drowsiness
- Nausea
Key clinical trials
- Effect of Melatonin Patches on Sleep in Urological Surgery (NA)
- The Efficacy of Melatonin Patches on Dental Anxiety in Children (PHASE4)
- : Association of Melatonin Levels and Light and Noise Isolation in ICU (NA)
- Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief (PHASE4)
- Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium (PHASE1, PHASE2)
- Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Melatonin Patches CI brief — competitive landscape report
- Melatonin Patches updates RSS · CI watch RSS
- Ain Shams University portfolio CI
Frequently asked questions about Melatonin Patches
What is Melatonin Patches?
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Is Melatonin Patches also known as anything else?
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Related
- Drug class: All Melatonin receptor agonist drugs
- Target: All drugs targeting MT1 and MT2 melatonin receptors
- Manufacturer: Ain Shams University — full pipeline
- Therapeutic area: All drugs in Neurology / Sleep Medicine
- Indication: Drugs for Insomnia and sleep disorders
- Indication: Drugs for Circadian rhythm sleep-wake disorders
- Also known as: Melatonin Stickers
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing