{"id":"melatonin-patches","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Skin irritation at patch site"},{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL45","moleculeType":"Small molecule","molecularWeight":"232.28"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Melatonin is an endogenous hormone that acts as a chronobiotic agent, synchronizing the body's internal clock with the external light-dark cycle. By activating melatonin receptors in the suprachiasmatic nucleus and other tissues, it facilitates sleep onset and maintains sleep-wake cycle homeostasis. The transdermal patch formulation provides sustained delivery to maintain therapeutic melatonin levels throughout the night.","oneSentence":"Melatonin binds to melatonin receptors (MT1 and MT2) to regulate circadian rhythm and promote sleep.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:15.191Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Insomnia and sleep disorders"},{"name":"Circadian rhythm sleep-wake disorders"}]},"trialDetails":[{"nctId":"NCT06910345","phase":"NA","title":"Effect of Melatonin Patches on Sleep in Urological Surgery","status":"COMPLETED","sponsor":"Atlas University","startDate":"2024-02-25","conditions":"Urological Surgery","enrollment":60},{"nctId":"NCT07162272","phase":"PHASE4","title":"The Efficacy of Melatonin Patches on Dental Anxiety in Children","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2025-06-25","conditions":"Dental Anxiety, Children","enrollment":52},{"nctId":"NCT03659760","phase":"NA","title":": Association of Melatonin Levels and Light and Noise Isolation in ICU","status":"COMPLETED","sponsor":"Diskapi Yildirim Beyazit Education and Research Hospital","startDate":"2018-09-03","conditions":"Cranial Nerve Diseases","enrollment":41},{"nctId":"NCT02747628","phase":"PHASE4","title":"Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2013-04","conditions":"Postoperative Pain Relief","enrollment":60},{"nctId":"NCT04189666","phase":"PHASE1, PHASE2","title":"Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2019-11-18","conditions":"Delirium","enrollment":180},{"nctId":"NCT02726126","phase":"","title":"Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2013-03","conditions":"Postoperative Pain","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Melatonin Stickers"],"phase":"marketed","status":"active","brandName":"Melatonin Patches","genericName":"Melatonin Patches","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Melatonin patches are a type of transdermal therapeutic system that contain 2.1 mg of melatonin, a small molecule that acts as a melatonin receptor agonist. These patches have been studied for various conditions, including urological surgery, postoperative pain relief, dental anxiety, and cranial nerve diseases, typically applied to the upper chest or forearm before sleep.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}