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Manual titration of propofol
Propofol is an intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anesthesia.
Propofol is an intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.
At a glance
| Generic name | Manual titration of propofol |
|---|---|
| Sponsor | Brugmann University Hospital |
| Drug class | Intravenous sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in depression of the central nervous system, producing rapid onset sedation, hypnosis, and anesthesia. Manual titration allows clinicians to adjust the infusion rate to achieve and maintain the desired level of sedation.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in mechanically ventilated patients in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming (NA)
- A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol (PHASE4)
- Automated Anesthesia Guided by the Conox Monitor for Surgery (NA)
- Design of a Closed-loop Controller Based on the Bispectral Index (BIS) Effectiveness of the Smith Predictor (NA)
- Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Manual titration of propofol CI brief — competitive landscape report
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- Brugmann University Hospital portfolio CI