{"id":"manual-titration-of-propofol","safety":{"commonSideEffects":[{"rate":"25-30","effect":"Hypotension"},{"rate":"20-30","effect":"Respiratory depression"},{"rate":"10-15","effect":"Bradycardia"},{"rate":"10-20","effect":"Injection site pain"},{"rate":"5-10","effect":"Apnea"},{"rate":null,"effect":"Propofol infusion syndrome (with prolonged use)"}]},"_chembl":{"chemblId":"CHEMBL526","moleculeType":"Small molecule","molecularWeight":"178.27"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in depression of the central nervous system, producing rapid onset sedation, hypnosis, and anesthesia. Manual titration allows clinicians to adjust the infusion rate to achieve and maintain the desired level of sedation.","oneSentence":"Propofol is an intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:53:52.220Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Sedation in mechanically ventilated patients in intensive care units"}]},"trialDetails":[{"nctId":"NCT07357480","phase":"NA","title":"Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery","status":"RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-01-14","conditions":"Postoperative Delirium (POD), Postoperative Pain, PONV","enrollment":70},{"nctId":"NCT03476213","phase":"NA","title":"Manual Versus Targer-controll Infusion in Reduction of Awareness and Dreaming","status":"RECRUITING","sponsor":"University Hospital Hradec Kralove","startDate":"2018-03-16","conditions":"Anesthesia Awareness","enrollment":80},{"nctId":"NCT02314559","phase":"PHASE4","title":"A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol","status":"COMPLETED","sponsor":"Brugmann University Hospital","startDate":"2015-02","conditions":"Colonoscopy (Ambulatory Patients)","enrollment":164},{"nctId":"NCT03540875","phase":"NA","title":"Automated Anesthesia Guided by the Conox Monitor for Surgery","status":"TERMINATED","sponsor":"CMC Ambroise Paré","startDate":"2018-07-02","conditions":"Anesthesia, General","enrollment":62},{"nctId":"NCT03073408","phase":"NA","title":"Design of a Closed-loop Controller Based on the Bispectral Index (BIS) Effectiveness of the Smith Predictor","status":"UNKNOWN","sponsor":"José Antonio Reboso Morales","startDate":"2017-03-06","conditions":"General Anesthesia","enrollment":50},{"nctId":"NCT01942356","phase":"NA","title":"Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2013-09","conditions":"Acute Cholecystitis, Chronic Cholecystitis","enrollment":4}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Manual titration of propofol","genericName":"Manual titration of propofol","companyName":"Brugmann University Hospital","companyId":"brugmann-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propofol is an intravenous sedative-hypnotic agent that enhances inhibitory GABAergic neurotransmission in the central nervous system to produce sedation and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in mechanically ventilated patients in intensive care units.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}