Last reviewed · How we verify
lobaplatin , 5-FU ,leucovorin
lobaplatin , 5-FU ,leucovorin is a Platinum-based chemotherapy Small molecule drug developed by Taian Cancer Hospital. It is currently in Phase 3 development for Metastatic colorectal cancer, Metastatic gastric cancer. Also known as: LBP ,5-FU,LV.
Lobaplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription.
Lobaplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription. Used for Metastatic colorectal cancer, Metastatic gastric cancer.
At a glance
| Generic name | lobaplatin , 5-FU ,leucovorin |
|---|---|
| Also known as | LBP ,5-FU,LV |
| Sponsor | Taian Cancer Hospital |
| Drug class | Platinum-based chemotherapy |
| Target | DNA |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Lobaplatin is a second-generation platinum compound that has been shown to be more potent than cisplatin in some preclinical studies. It is thought to exert its antitumor effects by forming platinum-DNA adducts, which interfere with DNA replication and transcription, ultimately leading to cell death.
Approved indications
- Metastatic colorectal cancer
- Metastatic gastric cancer
Common side effects
- Myelosuppression
- Nausea and vomiting
- Diarrhea
- Neutropenia
- Thrombocytopenia
Key clinical trials
- HAIC Versus TACE for Large Hepatocellular Carcinoma Staged BCLC A/B. (PHASE3)
- HAIC Versus TACE for Large and Unresectable Hepatocellular Carcinoma Staged BCLC A/B (PHASE2)
- Study of Lobaplatin，5-Fluorouracil and Leucovorin for the Treatment of Esophageal Carcinoma (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lobaplatin , 5-FU ,leucovorin CI brief — competitive landscape report
- lobaplatin , 5-FU ,leucovorin updates RSS · CI watch RSS
- Taian Cancer Hospital portfolio CI
Frequently asked questions about lobaplatin , 5-FU ,leucovorin
What is lobaplatin , 5-FU ,leucovorin?
How does lobaplatin , 5-FU ,leucovorin work?
What is lobaplatin , 5-FU ,leucovorin used for?
Who makes lobaplatin , 5-FU ,leucovorin?
Is lobaplatin , 5-FU ,leucovorin also known as anything else?
What drug class is lobaplatin , 5-FU ,leucovorin in?
What development phase is lobaplatin , 5-FU ,leucovorin in?
What are the side effects of lobaplatin , 5-FU ,leucovorin?
What does lobaplatin , 5-FU ,leucovorin target?
Related
- Drug class: All Platinum-based chemotherapy drugs
- Target: All drugs targeting DNA
- Manufacturer: Taian Cancer Hospital — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Metastatic colorectal cancer
- Indication: Drugs for Metastatic gastric cancer
- Also known as: LBP ,5-FU,LV
- Compare: lobaplatin , 5-FU ,leucovorin vs similar drugs
- Pricing: lobaplatin , 5-FU ,leucovorin cost, discount & access