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lipuro propofol
lipuro propofol is a GABA-A receptor positive allosteric modulator Small molecule drug developed by Institute of Child Health. It is currently FDA-approved for Induction and maintenance of general anesthesia in pediatric patients, Sedation in pediatric intensive care settings.
Lipuro propofol is a lipid emulsion formulation of propofol that acts as a positive allosteric modulator of GABA-A receptors to produce sedation and anesthesia.
Lipuro propofol is a lipid emulsion formulation of propofol that acts as a positive allosteric modulator of GABA-A receptors to produce sedation and anesthesia. Used for Induction and maintenance of general anesthesia in pediatric patients, Sedation in pediatric intensive care settings.
At a glance
| Generic name | lipuro propofol |
|---|---|
| Sponsor | Institute of Child Health |
| Drug class | GABA-A receptor positive allosteric modulator |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol enhances the inhibitory effects of gamma-aminobutyric acid (GABA) at GABA-A receptors in the central nervous system, leading to rapid onset sedation and hypnosis. The lipid emulsion formulation (Lipuro) improves solubility and reduces pain on injection compared to standard propofol formulations. This formulation is particularly used in pediatric anesthesia.
Approved indications
- Induction and maintenance of general anesthesia in pediatric patients
- Sedation in pediatric intensive care settings
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
Key clinical trials
- DISE in Pediatric Sleep Disordered Breathing (PHASE2, PHASE3)
- Respiratory Effect of the LISA Method with Sedation by Propofol Versus Absence of Sedation. (PHASE3)
- Effects Of Propofol-Dexmedetomıdıne And Propofol- Remıfentanıl In Hysteroscopıc Operations.
- Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia (PHASE4)
- Patient-controlled Sedation With Propofol Versus Combined Sedation During Bronchoscopy (NA)
- The Effect of Body Mass Index In Relation To Menstrual Cycle Phase on Propofol Injection Pain
- Remimazolam Phase II Cardiac Anesthesia Study (PHASE2)
- The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- lipuro propofol CI brief — competitive landscape report
- lipuro propofol updates RSS · CI watch RSS
- Institute of Child Health portfolio CI
Frequently asked questions about lipuro propofol
What is lipuro propofol?
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Related
- Drug class: All GABA-A receptor positive allosteric modulator drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: Institute of Child Health — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Induction and maintenance of general anesthesia in pediatric patients
- Indication: Drugs for Sedation in pediatric intensive care settings
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing