NCT01975064: CAN

A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer

Completed Phase 4 Last updated 12 December 2022

What this trial tests

Phase 4 trial testing Propofol in Breast Neoplasms in 5,774 participants. Completed in 31 August 2022.

Timeline

1 November 2013

Primary endpoint
31 August 2022

31 August 2022

Quick facts

Lead sponsor	Uppsala University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	5,774
Start date	1 November 2013
Primary completion	31 August 2022
Estimated completion	31 August 2022
Sites	15 locations across China, Poland, Sweden

Drugs / interventions tested

• Propofol (Propofol) — full drug profile →
• Sevoflurane — full drug profile →

Conditions studied

• Breast Neoplasms — all drugs for Breast Neoplasms →
• Colonic Neoplasms — all drugs for Colonic Neoplasms →
• Rectal Neoplasms — all drugs for Rectal Neoplasms →

Sponsor

Uppsala University

Who can join

18 and older, any sex, with Breast Neoplasms or Colonic Neoplasms. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

• Over all survival
  Time frame: Five years
  Measured from day of surgical procedure to day of death or day of censoring

Sponsor's own description

The purpose of this study is to determine whether anesthesia maintained with propofol results in better one- and five-year-survival than anesthesia maintained with sevoflurane.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence.
   Forget P, Aguirre JA, Bencic I, Borgeat A, et al · · 2019 · cited 48× · PMID 31035321 · DOI 10.3390/cancers11050592
2. Long-term prognosis after cancer surgery with inhalational anesthesia and total intravenous anesthesia: a systematic review and meta-analysis.
   Jin Z, Li R, Liu J, Lin J. · · 2019 · cited 31× · PMID 31333811
3. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane.
   Enlund M, Berglund A, Enlund A, Lundberg J, et al · · 2023 · cited 26× · PMID 37333664 · DOI 10.1016/j.eclinm.2023.102037
4. Anesthetic Strategies in Oncological Surgery: Not Only a Simple Sleep, but Also Impact on Immunosuppression and Cancer Recurrence.
   Longhini F, Bruni A, Garofalo E, De Sarro R, et al · · 2020 · cited 26× · PMID 32104075 · DOI 10.2147/cmar.s237224
5. Anesthetics or anesthetic techniques and cancer surgical outcomes: a possible link.
   Alam A, Rampes S, Patel S, Hana Z, et al · · 2021 · cited 22× · PMID 33596628 · DOI 10.4097/kja.20679
6. Anesthesia Techniques and Long-Term Oncological Outcomes.
   Ramirez MF, Cata JP. · · 2021 · cited 20× · PMID 34956903 · DOI 10.3389/fonc.2021.788918
7. Anesthesia and Cancer, Friend or Foe? A Narrative Review.
   Montejano J, Jevtovic-Todorovic V. · · 2021 · cited 16× · PMID 35004329 · DOI 10.3389/fonc.2021.803266
8. Current Status and Prospects of Anesthesia and Breast Cancer: Does Anesthetic Technique Affect Recurrence and Survival Rates in Breast Cancer Surgery?
   Kim R, Kawai A, Wakisaka M, Kin T. · · 2022 · cited 14× · PMID 35223475 · DOI 10.3389/fonc.2022.795864