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Lidocaine skin wheal

George Washington University · FDA-approved active Small molecule

Lidocaine skin wheal is a Local anesthetic Small molecule drug developed by George Washington University. It is currently FDA-approved for Local anesthesia for minor surgical procedures and injections via intradermal skin wheal.

Lidocaine blocks sodium channels in nerve fibers, preventing the initiation and conduction of action potentials to produce local anesthesia.

Lidocaine blocks sodium channels in nerve fibers, preventing the initiation and conduction of action potentials to produce local anesthesia at the injection site. Used for Local anesthesia for minor skin procedures and diagnostic procedures.

At a glance

Generic nameLidocaine skin wheal
SponsorGeorge Washington University
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia/Pain Management
PhaseFDA-approved

Mechanism of action

Lidocaine is a local anesthetic that works by reversibly inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. This prevents depolarization and the generation of action potentials, thereby blocking nerve conduction. When injected intradermally to form a skin wheal, it anesthetizes the local tissue area, making it useful for minor surgical procedures, injections, or other painful dermatological interventions.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Lidocaine skin wheal

What is Lidocaine skin wheal?

Lidocaine skin wheal is a Local anesthetic drug developed by George Washington University, indicated for Local anesthesia for minor surgical procedures and injections via intradermal skin wheal.

How does Lidocaine skin wheal work?

Lidocaine blocks sodium channels in nerve fibers, preventing the initiation and conduction of action potentials to produce local anesthesia.

What is Lidocaine skin wheal used for?

Lidocaine skin wheal is indicated for Local anesthesia for minor surgical procedures and injections via intradermal skin wheal.

Who makes Lidocaine skin wheal?

Lidocaine skin wheal is developed and marketed by George Washington University (see full George Washington University pipeline at /company/george-washington-university).

What drug class is Lidocaine skin wheal in?

Lidocaine skin wheal belongs to the Local anesthetic class. See all Local anesthetic drugs at /class/local-anesthetic.

What development phase is Lidocaine skin wheal in?

Lidocaine skin wheal is FDA-approved (marketed).

What are the side effects of Lidocaine skin wheal?

Common side effects of Lidocaine skin wheal include Local erythema or edema at injection site, Transient burning or stinging at injection site, Allergic contact dermatitis (rare).

What does Lidocaine skin wheal target?

Lidocaine skin wheal targets Voltage-gated sodium channels and is a Local anesthetic.

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