Last reviewed · How we verify

Lidocaine (drug)

Daniel A Tonetti, MD · FDA-approved active Small molecule

Lidocaine (drug) is a Local anesthetic Small molecule drug developed by Daniel A Tonetti, MD. It is currently FDA-approved for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (intravenous formulation), Topical pain relief for minor cuts, burns, and mucous membrane procedures. Also known as: Xylocaine, Lidocaine IV, Lidocaine 2%, magnisium sulfate.

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (intravenous formulation), Topical pain relief for minor cuts, burns, and mucous membrane procedures.

At a glance

Generic nameLidocaine (drug)
Also known asXylocaine, Lidocaine IV, Lidocaine 2%, magnisium sulfate, saline
SponsorDaniel A Tonetti, MD
Drug classLocal anesthetic
TargetVoltage-gated sodium channels
ModalitySmall molecule
Therapeutic areaAnesthesia/Pain Management
PhaseFDA-approved

Mechanism of action

Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission along nerves. It can be used topically, by infiltration, or by regional/nerve block injection depending on the clinical indication.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Frequently asked questions about Lidocaine (drug)

What is Lidocaine (drug)?

Lidocaine (drug) is a Local anesthetic drug developed by Daniel A Tonetti, MD, indicated for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (intravenous formulation), Topical pain relief for minor cuts, burns, and mucous membrane procedures.

How does Lidocaine (drug) work?

Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.

What is Lidocaine (drug) used for?

Lidocaine (drug) is indicated for Local anesthesia for infiltration, nerve block, and topical use, Ventricular arrhythmias (intravenous formulation), Topical pain relief for minor cuts, burns, and mucous membrane procedures.

Who makes Lidocaine (drug)?

Lidocaine (drug) is developed and marketed by Daniel A Tonetti, MD (see full Daniel A Tonetti, MD pipeline at /company/daniel-a-tonetti-md).

Is Lidocaine (drug) also known as anything else?

Lidocaine (drug) is also known as Xylocaine, Lidocaine IV, Lidocaine 2%, magnisium sulfate, saline.

What drug class is Lidocaine (drug) in?

Lidocaine (drug) belongs to the Local anesthetic class. See all Local anesthetic drugs at /class/local-anesthetic.

What development phase is Lidocaine (drug) in?

Lidocaine (drug) is FDA-approved (marketed).

What are the side effects of Lidocaine (drug)?

Common side effects of Lidocaine (drug) include Injection site reactions, Dizziness or lightheadedness, Tremor or nervousness, Allergic reactions (rare with amide lidocaine), Methemoglobinemia (with topical spray overuse).

What does Lidocaine (drug) target?

Lidocaine (drug) targets Voltage-gated sodium channels and is a Local anesthetic.

Related