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Lidocaine and sodium bicarbonate
Lidocaine and sodium bicarbonate is a Local anesthetic Small molecule drug developed by University of Zurich. It is currently FDA-approved for Local and regional anesthesia.
Lidocaine blocks sodium channels to provide local anesthesia, while sodium bicarbonate buffers the solution to reduce pain on injection and improve efficacy.
Lidocaine blocks sodium channels to provide local anesthesia, while sodium bicarbonate buffers the solution to reduce pain on injection and improve efficacy. Used for Local and regional anesthesia.
At a glance
| Generic name | Lidocaine and sodium bicarbonate |
|---|---|
| Sponsor | University of Zurich |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes, preventing depolarization and blocking nerve conduction. Sodium bicarbonate raises the pH of the lidocaine solution, increasing the proportion of non-ionized lidocaine that can penetrate nerve tissue more readily, thereby enhancing anesthetic onset and reducing injection pain from the acidic lidocaine formulation.
Approved indications
- Local and regional anesthesia
Common side effects
- Injection site pain
- Transient paresthesia
- Allergic reactions
Key clinical trials
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- The Effect of Local Anesthesia Techniques on Postoperative Pain After Laser Treatment of Pilonidal Sinus (NA)
- Split Face Study of the Duration of Local Anesthetics - Fourth Arm (PHASE4)
- WALANT Versus Local Anesthesia in Central Venous Catheter Insertion (NA)
- Ringer Acetate Based Modified Del Nido Cardioplegia Solution Versus HTK Solution Cardioplegia Solution in Cardiac Surgery (PHASE3)
- The Effectiveness of Intracuff Dexmedetomidine in Preventing Postoperative Sore Throat Following Prone Surgery (PHASE2)
- Carpal Tunnel Release Under Local Anaesthesia With or Without Distal Median Nerve Block (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine and sodium bicarbonate CI brief — competitive landscape report
- Lidocaine and sodium bicarbonate updates RSS · CI watch RSS
- University of Zurich portfolio CI
Frequently asked questions about Lidocaine and sodium bicarbonate
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Zurich — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local and regional anesthesia
- Compare: Lidocaine and sodium bicarbonate vs similar drugs
- Pricing: Lidocaine and sodium bicarbonate cost, discount & access