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Levothyroxin-Na
Levothyroxine sodium is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function.
Levothyroxine sodium is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function. Used for Hypothyroidism, Thyroid cancer suppression therapy, Myxedema coma.
At a glance
| Generic name | Levothyroxin-Na |
|---|---|
| Sponsor | Sanofi |
| Drug class | Thyroid hormone replacement |
| Target | Thyroid hormone receptors (TR-alpha and TR-beta) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Levothyroxine (T4) is converted peripherally to the active form triiodothyronine (T3), which binds to thyroid hormone receptors in target tissues to regulate metabolism, growth, and development. It is used to treat hypothyroidism by restoring adequate circulating thyroid hormone levels and normalizing TSH feedback. The drug increases metabolic rate and energy expenditure across multiple organ systems.
Approved indications
- Hypothyroidism
- Thyroid cancer suppression therapy
- Myxedema coma
Common side effects
- Tachycardia
- Tremor
- Anxiety
- Insomnia
- Heat intolerance
- Weight loss
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |