{"id":"levothyroxin-na","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Heat intolerance"},{"rate":null,"effect":"Weight loss"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levothyroxine (T4) is converted peripherally to the active form triiodothyronine (T3), which binds to thyroid hormone receptors in target tissues to regulate metabolism, growth, and development. It is used to treat hypothyroidism by restoring adequate circulating thyroid hormone levels and normalizing TSH feedback. The drug increases metabolic rate and energy expenditure across multiple organ systems.","oneSentence":"Levothyroxine sodium is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:52:05.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypothyroidism"},{"name":"Thyroid cancer suppression therapy"},{"name":"Myxedema coma"}]},"trialDetails":[{"nctId":"NCT00277589","phase":"PHASE4","title":"LISA-study : Levothyroxin in Nodular Goiter","status":"COMPLETED","sponsor":"Sanofi","startDate":"2004-05","conditions":"Goiter, Nodular","enrollment":1024}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"HEADACHE"},{"count":1,"reaction":"INTENTIONAL PRODUCT MISUSE"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levothyroxin-Na","genericName":"Levothyroxin-Na","companyName":"Sanofi","companyId":"sanofi","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levothyroxine sodium is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function. Used for Hypothyroidism, Thyroid cancer suppression therapy, Myxedema coma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}