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Levobupivacaine 0,5%
Levobupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.
Levobupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Levobupivacaine 0,5% |
|---|---|
| Sponsor | ASST Gaetano Pini-CTO |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
As the S-enantiomer of bupivacaine, levobupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers. This prevents depolarization and transmission of nerve impulses, resulting in local anesthesia. Levobupivacaine has a lower cardiotoxicity profile compared to racemic bupivacaine due to reduced myocardial sodium channel blockade.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Headache
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery (NA)
- Comparative Evaluation of Two Different Post-Operative Analgesia After Hallux Valgus Correction
- Caudal Dexmedetomidine Analgesia in Pediatrics . (NA)
- Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoids (NA)
- Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement. (NA)
- Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) (PHASE3)
- Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Levobupivacaine 0,5% CI brief — competitive landscape report
- Levobupivacaine 0,5% updates RSS · CI watch RSS
- ASST Gaetano Pini-CTO portfolio CI