{"id":"levobupivacaine-0-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Systemic toxicity (CNS and cardiac effects at high doses)"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As the S-enantiomer of bupivacaine, levobupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve fibers. This prevents depolarization and transmission of nerve impulses, resulting in local anesthesia. Levobupivacaine has a lower cardiotoxicity profile compared to racemic bupivacaine due to reduced myocardial sodium channel blockade.","oneSentence":"Levobupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:06.998Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local and regional anesthesia for surgical procedures"},{"name":"Infiltration anesthesia"},{"name":"Nerve blocks"},{"name":"Epidural anesthesia"}]},"trialDetails":[{"nctId":"NCT06042816","phase":"NA","title":"Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery","status":"COMPLETED","sponsor":"Vietnam Military Medical University","startDate":"2019-12-30","conditions":"Colorectal Cancer","enrollment":49},{"nctId":"NCT03396991","phase":"","title":"Comparative Evaluation of Two Different Post-Operative Analgesia After Hallux Valgus Correction","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2017-07-01","conditions":"Pain, Postoperative","enrollment":26},{"nctId":"NCT03791879","phase":"NA","title":"Caudal Dexmedetomidine Analgesia in Pediatrics .","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2019-01-01","conditions":"164 Boys for Hypospadias Surgery Under General Anesthesia With Caudal Block","enrollment":164},{"nctId":"NCT03298997","phase":"NA","title":"Ligation and Hemorrhoidopexy Technique Versus Ligation of Hemorrhoidal Arteries Using Ultrasound for Hemorrhoids","status":"COMPLETED","sponsor":"Larissa University Hospital","startDate":"2017-10-01","conditions":"Hemorrhoids","enrollment":60},{"nctId":"NCT02288923","phase":"NA","title":"Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.","status":"COMPLETED","sponsor":"Royal Devon and Exeter NHS Foundation Trust","startDate":"2015-03","conditions":"Arthritis Knee","enrollment":199},{"nctId":"NCT02563821","phase":"PHASE3","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2015-11-05","conditions":"Anesthesia, Epidural","enrollment":37},{"nctId":"NCT01249872","phase":"PHASE2, PHASE3","title":"Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens","status":"COMPLETED","sponsor":"University of Patras","startDate":"2010-01","conditions":"Morbid Obesity, Postoperative Pain, Postoperative Bowel Function","enrollment":96}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":138,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levobupivacaine 0,5%","genericName":"Levobupivacaine 0,5%","companyName":"ASST Gaetano Pini-CTO","companyId":"asst-gaetano-pini-cto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce local anesthesia. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}