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L-Thyroxine (tablet, per os)
L-Thyroxine (tablet, per os) is a Thyroid hormone replacement Small molecule drug developed by Meyer Children's Hospital IRCCS. It is currently FDA-approved for Hypothyroidism, Thyroid cancer (suppressive therapy), Myxedema coma. Also known as: Eutirox.
L-Thyroxine is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function.
L-Thyroxine, also known as levothyroxine, is a medication used to treat conditions such as subclinical hypothyroidism and congenital hypothyroidism. It is also studied in relation to iron deficiency anemia and endometrial thickness, but its exact role in these conditions is not specified in the provided facts.
At a glance
| Generic name | L-Thyroxine (tablet, per os) |
|---|---|
| Also known as | Eutirox |
| Sponsor | Meyer Children's Hospital IRCCS |
| Drug class | Thyroid hormone replacement |
| Target | Thyroid hormone receptors (TR-alpha, TR-beta) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology |
| Phase | FDA-approved |
Mechanism of action
L-Thyroxine (levothyroxine) is converted peripherally to the active form L-triiodothyronine (T3), which binds to thyroid hormone receptors in target tissues to regulate metabolism, growth, and development. It is used to treat hypothyroidism by restoring circulating thyroid hormone levels to normal physiological ranges, thereby normalizing metabolic rate, energy production, and other thyroid-dependent functions.
Approved indications
- Hypothyroidism
- Thyroid cancer (suppressive therapy)
- Myxedema coma
Common side effects
- Tachycardia
- Tremor
- Anxiety
- Insomnia
- Heat intolerance
- Weight loss
Key clinical trials
- COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer (PHASE2)
- Sunitinib or Cediranib for Alveolar Soft Part Sarcoma (PHASE2)
- Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity. (PHASE3)
- A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants (PHASE2, PHASE3)
- Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH) (PHASE4)
- Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-Ab (NA)
- Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism (NA)
- Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- L-Thyroxine (tablet, per os) CI brief — competitive landscape report
- L-Thyroxine (tablet, per os) updates RSS · CI watch RSS
- Meyer Children's Hospital IRCCS portfolio CI
Frequently asked questions about L-Thyroxine (tablet, per os)
What is L-Thyroxine (tablet, per os)?
How does L-Thyroxine (tablet, per os) work?
What is L-Thyroxine (tablet, per os) used for?
Who makes L-Thyroxine (tablet, per os)?
Is L-Thyroxine (tablet, per os) also known as anything else?
What drug class is L-Thyroxine (tablet, per os) in?
What development phase is L-Thyroxine (tablet, per os) in?
What are the side effects of L-Thyroxine (tablet, per os)?
What does L-Thyroxine (tablet, per os) target?
Related
- Drug class: All Thyroid hormone replacement drugs
- Target: All drugs targeting Thyroid hormone receptors (TR-alpha, TR-beta)
- Manufacturer: Meyer Children's Hospital IRCCS — full pipeline
- Therapeutic area: All drugs in Endocrinology
- Indication: Drugs for Hypothyroidism
- Indication: Drugs for Thyroid cancer (suppressive therapy)
- Indication: Drugs for Myxedema coma
- Also known as: Eutirox
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing