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It is used to treat hypothyroidism by restoring circulating thyroid hormone levels to normal physiological ranges, thereby normalizing metabolic rate, energy production, and other thyroid-dependent functions.","oneSentence":"L-Thyroxine is a synthetic thyroid hormone that replaces or supplements endogenous thyroid hormone to restore normal metabolic function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:33:47.994Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypothyroidism"},{"name":"Thyroid cancer (suppressive therapy)"},{"name":"Myxedema coma"}]},"trialDetails":[{"nctId":"NCT06790589","phase":"PHASE2","title":"COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer","status":"NOT_YET_RECRUITING","sponsor":"AHS Cancer Control Alberta","startDate":"2026-12","conditions":"Advanced Differentiated Thyroid Gland 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