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Korean Red Ginseng (KRG)
Korean Red Ginseng contains ginsenosides and other bioactive compounds that modulate immune function, reduce inflammation, and enhance antioxidant activity.
Korean Red Ginseng contains ginsenosides and other bioactive compounds that modulate immune function, reduce inflammation, and enhance antioxidant activity. Used for Fatigue and energy enhancement, Immune function support, Stress and adaptation.
At a glance
| Generic name | Korean Red Ginseng (KRG) |
|---|---|
| Sponsor | Pusan National University Hospital |
| Drug class | Herbal adaptogen / immunomodulator |
| Modality | Small molecule |
| Therapeutic area | Immunology, General wellness, Fatigue |
| Phase | FDA-approved |
Mechanism of action
KRG's active constituents, particularly ginsenosides (Rb1, Rg1, Re, etc.), interact with multiple cellular pathways including toll-like receptors, nuclear factor-kappa B signaling, and mitochondrial function. These interactions promote natural killer cell activity, enhance T-cell proliferation, suppress pro-inflammatory cytokine production, and scavenge reactive oxygen species. The polysaccharide and polyphenol fractions also contribute to immunomodulatory and cytoprotective effects.
Approved indications
- Fatigue and energy enhancement
- Immune function support
- Stress and adaptation
- Cognitive function and memory
Common side effects
- Insomnia or sleep disturbance
- Headache
- Gastrointestinal upset
- Nervousness or anxiety
Key clinical trials
- Impact of Korean Red Ginseng on Fatigue in Patients With Rheumatic Disease (NA)
- Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study (PHASE4)
- Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation (PHASE2)
- Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis (PHASE4)
- Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension (PHASE2)
- Effects of Korean Red Ginseng on Male Infertility (PHASE4)
- Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure (PHASE1)
- The Effect of Korean Red Ginseng Supplementation on Glucose Control (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Korean Red Ginseng (KRG) CI brief — competitive landscape report
- Korean Red Ginseng (KRG) updates RSS · CI watch RSS
- Pusan National University Hospital portfolio CI