{"id":"korean-red-ginseng-krg","safety":{"commonSideEffects":[{"rate":null,"effect":"Insomnia or sleep disturbance"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nervousness or anxiety"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"KRG's active constituents, particularly ginsenosides (Rb1, Rg1, Re, etc.), interact with multiple cellular pathways including toll-like receptors, nuclear factor-kappa B signaling, and mitochondrial function. These interactions promote natural killer cell activity, enhance T-cell proliferation, suppress pro-inflammatory cytokine production, and scavenge reactive oxygen species. The polysaccharide and polyphenol fractions also contribute to immunomodulatory and cytoprotective effects.","oneSentence":"Korean Red Ginseng contains ginsenosides and other bioactive compounds that modulate immune function, reduce inflammation, and enhance antioxidant activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:19.378Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Fatigue and energy enhancement"},{"name":"Immune function support"},{"name":"Stress and adaptation"},{"name":"Cognitive function and memory"}]},"trialDetails":[{"nctId":"NCT03983408","phase":"NA","title":"Impact of Korean Red Ginseng on Fatigue in Patients With Rheumatic Disease","status":"UNKNOWN","sponsor":"Hanyang University","startDate":"2019-06-17","conditions":"Sjögren's Syndrome, Rheumatic Diseases, Korean Red Ginseng","enrollment":120},{"nctId":"NCT02204826","phase":"PHASE4","title":"Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study","status":"COMPLETED","sponsor":"Pusan National University Hospital","startDate":"2011-04","conditions":"Male Infertility","enrollment":80},{"nctId":"NCT00728221","phase":"PHASE2","title":"Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2007-11","conditions":"Hypertension, Blood Pressure, Endothelial Function","enrollment":17},{"nctId":"NCT02331589","phase":"PHASE4","title":"Anti-fatigue Effect of Korean Red Ginseng in Patients With Non-alcoholic Hepatitis","status":"COMPLETED","sponsor":"Chuncheon Sacred Heart Hospital","startDate":"2011-08","conditions":"Fatigue","enrollment":75},{"nctId":"NCT02211352","phase":"PHASE2","title":"Effect of Korean Red Ginseng on Central Blood Pressure in Patient With Essential Hypertension","status":"COMPLETED","sponsor":"Daegu Catholic University Medical Center","startDate":"2012-05","conditions":"Hypertension","enrollment":58},{"nctId":"NCT02202382","phase":"PHASE4","title":"Effects of Korean Red Ginseng on Male Infertility","status":"COMPLETED","sponsor":"Pusan National University Hospital","startDate":"2011-04","conditions":"Male Infertility","enrollment":80},{"nctId":"NCT01951443","phase":"PHASE1","title":"Korean Red Ginseng Rg3 Extract on Arterial Stiffness and Blood Pressure","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2013-08","conditions":"Arterial Stiffness, Blood Pressure","enrollment":24},{"nctId":"NCT01911663","phase":"PHASE4","title":"The Effect of Korean Red Ginseng Supplementation on Glucose Control","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2011-11","conditions":"Diabetes","enrollment":60},{"nctId":"NCT01478009","phase":"PHASE2, PHASE3","title":"Efficacy of an Extract of Concentrated Korean Red Ginseng for Preventing Upper Respiratory Tract Infections","status":"COMPLETED","sponsor":"Chonbuk National University Hospital","startDate":"2010-11","conditions":"Healthy Subjects","enrollment":100},{"nctId":"NCT00911768","phase":"PHASE4","title":"Effect of Korean Red Ginseng (KRG) on Dry Mouth","status":"COMPLETED","sponsor":"The Korean Society of Ginseng","startDate":"2007-09","conditions":"Xerostomia","enrollment":100}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ACQUIRED GENE MUTATION"},{"count":1,"reaction":"DEATH"},{"count":1,"reaction":"DRUG RESISTANCE"},{"count":1,"reaction":"TREATMENT FAILURE"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Korean Red Ginseng (KRG)","genericName":"Korean Red Ginseng (KRG)","companyName":"Pusan National University Hospital","companyId":"pusan-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Korean Red Ginseng contains ginsenosides and other bioactive compounds that modulate immune function, reduce inflammation, and enhance antioxidant activity. Used for Fatigue and energy enhancement, Immune function support, Stress and adaptation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}