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Effects of Korean Red Ginseng on Male Infertility
Objective: Several in vitro studies report positive effects of ginseng on spermatogenesis. However, no controlled human clinical study of the effect of Korean red ginseng (KRG) on spermatogenesis has been performed. This study was performed to investigate the effects of KRG on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study. Methods: A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-V + P group, placebo; V + P group, placebo and varicocelectomy; non-V + KRG group, 1.5-g KRG daily; V + KGR group, 1.5-g KRG daily and varicocelectomy. Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks.
Details
| Lead sponsor | Pusan National University Hospital |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 80 |
| Start date | 2011-04 |
Conditions
- Male Infertility
Interventions
- Korean Red Ginseng, Varicocelectomy
- Placebo
- Varicocelectomy
Primary outcomes
- Sperm concentration — When 12 week treatments were finished in all treatment arms, semen analysis and determination of hormonal levels were performed after 2 weeks of washout period
Primary outcome measure according to World Health Organization (WHO) methodologies (4th edition) - Sperm motility — When 12 week treatments were finished in all treatment arms, semen analysis and determination of hormonal levels were performed after 2 weeks of washout period
Primary outcome measure according to World Health Organization (WHO) methodologies (4th edition) - Sperm morphology — When 12 week treatments were finished in all treatment arms, semen analysis and determination of hormonal levels were performed after 2 weeks of washout period
Primary outcome measure according to World Health Organization (WHO) methodologies (4th edition) - Sperm viability — When 12 week treatments were finished in all treatment arms, semen analysis and determination of hormonal levels were performed after 2 weeks of washout period
Primary outcome measure according to World Health Organization (WHO) methodologies (4th edition)
Countries
South Korea