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Ketamina-Propofol Combination
Ketamina-Propofol Combination is a Anesthetic combination Small molecule drug developed by Universidad de Cartagena. It is currently FDA-approved for Induction and maintenance of general anesthesia, Procedural sedation. Also known as: Ketofol.
A combination of ketamine (NMDA receptor antagonist) and propofol (GABA-A agonist) that produces rapid anesthesia and sedation through dual CNS depression pathways.
A combination of ketamine (NMDA receptor antagonist) and propofol (GABA-A agonist) that produces rapid anesthesia and sedation through dual CNS depression pathways. Used for Induction and maintenance of general anesthesia, Procedural sedation.
At a glance
| Generic name | Ketamina-Propofol Combination |
|---|---|
| Also known as | Ketofol |
| Sponsor | Universidad de Cartagena |
| Drug class | Anesthetic combination |
| Target | NMDA receptor (ketamine); GABA-A receptor (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Ketamine blocks N-methyl-D-aspartate (NMDA) glutamate receptors to provide dissociative anesthesia and analgesia, while propofol enhances GABAergic inhibitory neurotransmission to produce sedation and hypnosis. The combination leverages synergistic effects to achieve faster induction, reduced dosing requirements, and potentially improved hemodynamic stability compared to either agent alone.
Approved indications
- Induction and maintenance of general anesthesia
- Procedural sedation
Common side effects
- Hypotension
- Respiratory depression
- Emergence reactions (ketamine-related)
- Injection site pain (propofol-related)
- Dissociation
Key clinical trials
- Effects of Different Sedation Techniques on Early Cognitive Recovery After Ambulatory Gynecologic Surgery (NA)
- Ketamine Augmentation of ECT in Treatment-Resistant Depression (PHASE3)
- Ketamine Versus Dexmedetomidine for Prevention of Postoperative Delirium (NA)
- Combined Ketamine/Propofol for Emergency Department Procedural Sedation (NA)
- Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus (PHASE2, PHASE3)
- Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy (PHASE4)
- Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries (EARLY_PHASE1)
- Efficacy of Ketamine-Propofol for Short Surgical Procedures (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketamina-Propofol Combination CI brief — competitive landscape report
- Ketamina-Propofol Combination updates RSS · CI watch RSS
- Universidad de Cartagena portfolio CI
Frequently asked questions about Ketamina-Propofol Combination
What is Ketamina-Propofol Combination?
How does Ketamina-Propofol Combination work?
What is Ketamina-Propofol Combination used for?
Who makes Ketamina-Propofol Combination?
Is Ketamina-Propofol Combination also known as anything else?
What drug class is Ketamina-Propofol Combination in?
What development phase is Ketamina-Propofol Combination in?
What are the side effects of Ketamina-Propofol Combination?
What does Ketamina-Propofol Combination target?
Related
- Drug class: All Anesthetic combination drugs
- Target: All drugs targeting NMDA receptor (ketamine); GABA-A receptor (propofol)
- Manufacturer: Universidad de Cartagena — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction and maintenance of general anesthesia
- Indication: Drugs for Procedural sedation
- Also known as: Ketofol
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing