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Irrigation with PVI
Irrigation with PVI is a Antiseptic/Antimicrobial agent Small molecule drug developed by The University of Texas Health Science Center, Houston. It is currently FDA-approved for Surgical site irrigation and antisepsis, Wound irrigation and cleansing, Prevention of surgical site infections.
Povidone-iodine (PVI) irrigation acts as a broad-spectrum antimicrobial agent that kills bacteria, fungi, and viruses through oxidative damage to microbial cell membranes and nucleic acids.
Povidone-iodine (PVI) irrigation acts as a broad-spectrum antimicrobial agent that kills bacteria, fungi, and viruses through oxidative damage to microbial cell membranes and nucleic acids. Used for Surgical site irrigation and antisepsis, Wound irrigation and cleansing, Prevention of surgical site infections.
At a glance
| Generic name | Irrigation with PVI |
|---|---|
| Sponsor | The University of Texas Health Science Center, Houston |
| Drug class | Antiseptic/Antimicrobial agent |
| Modality | Small molecule |
| Therapeutic area | Infection prevention / Surgical care |
| Phase | FDA-approved |
Mechanism of action
Povidone-iodine is an iodine-based antiseptic that releases free iodine when applied to tissues. The iodine penetrates microbial cell walls and disrupts essential cellular functions by oxidizing proteins, nucleic acids, and other critical molecules. It is commonly used as a topical irrigation solution in surgical and wound care settings to reduce infection risk.
Approved indications
- Surgical site irrigation and antisepsis
- Wound irrigation and cleansing
- Prevention of surgical site infections
Common side effects
- Local irritation or burning at application site
- Allergic reaction (iodine sensitivity)
- Staining of skin and tissues
Key clinical trials
- APPI-Cost Trial for Perforated Appendicitis (PHASE4)
- Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study (PHASE4)
- Prospective Evaluation of Biophysical Parameters as Long-term Predictors of Pulmonary Vein Isolation (NA)
- Personalized Atrial Fibrillation Ablation With QDOT (PHASE4)
- Added Value of SVC Isolation in Patients With Pulmonary Vein Reconnection Undergoing Repeat Ablation for Recurrent Paroxysmal AF (NA)
- Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis (PHASE2)
- ICE: Intracardiac Ultrasound Within the Left Atrium During Radiofrequency Ablation of Nonvalvular Atrial Fibrillation (NA)
- Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Irrigation with PVI CI brief — competitive landscape report
- Irrigation with PVI updates RSS · CI watch RSS
- The University of Texas Health Science Center, Houston portfolio CI
Frequently asked questions about Irrigation with PVI
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Related
- Drug class: All Antiseptic/Antimicrobial agent drugs
- Manufacturer: The University of Texas Health Science Center, Houston — full pipeline
- Therapeutic area: All drugs in Infection prevention / Surgical care
- Indication: Drugs for Surgical site irrigation and antisepsis
- Indication: Drugs for Wound irrigation and cleansing
- Indication: Drugs for Prevention of surgical site infections
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing