{"id":"irrigation-with-pvi","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Allergic reaction (iodine sensitivity)"},{"rate":null,"effect":"Staining of skin and tissues"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Povidone-iodine is an iodine-based antiseptic that releases free iodine when applied to tissues. The iodine penetrates microbial cell walls and disrupts essential cellular functions by oxidizing proteins, nucleic acids, and other critical molecules. It is commonly used as a topical irrigation solution in surgical and wound care settings to reduce infection risk.","oneSentence":"Povidone-iodine (PVI) irrigation acts as a broad-spectrum antimicrobial agent that kills bacteria, fungi, and viruses through oxidative damage to microbial cell membranes and nucleic acids.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:50:18.755Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site irrigation and antisepsis"},{"name":"Wound irrigation and cleansing"},{"name":"Prevention of surgical site infections"}]},"trialDetails":[{"nctId":"NCT06705842","phase":"PHASE4","title":"APPI-Cost Trial for Perforated Appendicitis","status":"RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2025-04-07","conditions":"Perforated Appendicitis","enrollment":346},{"nctId":"NCT04200729","phase":"PHASE4","title":"Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study","status":"NOT_YET_RECRUITING","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2027-03-01","conditions":"Acute, Perforated Appendicitis","enrollment":1750},{"nctId":"NCT05805189","phase":"NA","title":"Prospective Evaluation of Biophysical Parameters as Long-term Predictors of Pulmonary Vein Isolation","status":"RECRUITING","sponsor":"Maria Cecilia Hospital","startDate":"2023-02-09","conditions":"Atrial Fibrillation","enrollment":60},{"nctId":"NCT04298177","phase":"PHASE4","title":"Personalized Atrial Fibrillation Ablation With QDOT","status":"UNKNOWN","sponsor":"Antonio Berruezo, MD, PhD","startDate":"2022-03-01","conditions":"Atrial Fibrillation","enrollment":77},{"nctId":"NCT04602169","phase":"NA","title":"Added Value of SVC Isolation in Patients With Pulmonary Vein Reconnection Undergoing Repeat Ablation for Recurrent Paroxysmal AF","status":"UNKNOWN","sponsor":"AZ Sint-Jan AV","startDate":"2020-11-16","conditions":"Paroxysmal Atrial Fibrillation","enrollment":108},{"nctId":"NCT02664220","phase":"PHASE2","title":"Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2016-04","conditions":"Acute, Perforated Appendicitis","enrollment":100},{"nctId":"NCT02028143","phase":"NA","title":"ICE: Intracardiac Ultrasound Within the Left Atrium During Radiofrequency Ablation of Nonvalvular Atrial Fibrillation","status":"COMPLETED","sponsor":"Gregory Jones","startDate":"2013-11","conditions":"Atrial Fibrillation","enrollment":20},{"nctId":"NCT01952743","phase":"NA","title":"Renal Denervation Therapy in Hypertensive Patients Undergoing A-Fib Ablation","status":"TERMINATED","sponsor":"Siva Mulpuru","startDate":"2013-09","conditions":"Atrial Fibrillation, Hypertension","enrollment":3},{"nctId":"NCT02002923","phase":"PHASE2","title":"Pulmonary Vein Isolation Versus Botulinum Toxin Injection Plus Pulmonary Vein Isolation in Patients With Atrial Fibrillation","status":"UNKNOWN","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2013-06","conditions":"Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation","enrollment":160},{"nctId":"NCT01117025","phase":"PHASE2","title":"Combined Treatment of Resistant Hypertension and Atrial Fibrillation","status":"COMPLETED","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2010-04","conditions":"Hypertension, Resistant to Conventional Therapy, Atrial Fibrillation","enrollment":26},{"nctId":"NCT01709682","phase":"PHASE2","title":"A Comparison of the Drug Therapy Versus Re-Ablation","status":"COMPLETED","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2007-11","conditions":"Paroxysmal Atrial Fibrillation, Failed First Radiofrequency Ablation Procedure","enrollment":154},{"nctId":"NCT01164319","phase":"PHASE3","title":"\"UNMASKING Study\" For Atrial Fibrillation Recurrences Typing in Early Postoperative Period","status":"COMPLETED","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2008-02","conditions":"Atrial Fibrillation","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":203,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Irrigation with PVI","genericName":"Irrigation with PVI","companyName":"The University of Texas Health Science Center, Houston","companyId":"the-university-of-texas-health-science-center-houston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Povidone-iodine (PVI) irrigation acts as a broad-spectrum antimicrobial agent that kills bacteria, fungi, and viruses through oxidative damage to microbial cell membranes and nucleic acids. Used for Surgical site irrigation and antisepsis, Wound irrigation and cleansing, Prevention of surgical site infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}