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IPACK and multi-modal analgesic regimen
IPACK and multi-modal analgesic regimen is a Small molecule drug developed by University Health Network, Toronto. It is currently FDA-approved for Postoperative pain management following shoulder surgery, Postoperative pain management following upper extremity surgery. Also known as: Infilteration between popliteal artery and posterior capsule of the knee.
IPACK (Interscalene block, Pecs block, Axillary block, and Knee block) combined with multi-modal analgesia delivers regional anesthesia and systemic pain relief to reduce postoperative pain and opioid consumption.
IPACK (Interscalene block, Pecs block, Axillary block, and Knee block) combined with multi-modal analgesia delivers regional anesthesia and systemic pain relief to reduce postoperative pain and opioid consumption. Used for Postoperative pain management following shoulder surgery, Postoperative pain management following upper extremity surgery.
At a glance
| Generic name | IPACK and multi-modal analgesic regimen |
|---|---|
| Also known as | Infilteration between popliteal artery and posterior capsule of the knee |
| Sponsor | University Health Network, Toronto |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
IPACK is a regional anesthesia technique that blocks multiple nerve pathways (interscalene, pectoral, axillary, and knee blocks) to provide localized pain control in the shoulder and upper extremity. When combined with a multi-modal analgesic regimen (typically including NSAIDs, acetaminophen, and other non-opioid agents), it provides comprehensive perioperative pain management that reduces reliance on opioid medications and improves recovery outcomes.
Approved indications
- Postoperative pain management following shoulder surgery
- Postoperative pain management following upper extremity surgery
Common side effects
- Nerve injury or neuropraxia
- Vascular puncture
- Local anesthetic toxicity
- Hematoma
Key clinical trials
- Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries (PHASE1, PHASE2)
- IPACK Study in Total Knee Arthroplasty Patients (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IPACK and multi-modal analgesic regimen CI brief — competitive landscape report
- IPACK and multi-modal analgesic regimen updates RSS · CI watch RSS
- University Health Network, Toronto portfolio CI
Frequently asked questions about IPACK and multi-modal analgesic regimen
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Related
- Manufacturer: University Health Network, Toronto — full pipeline
- Therapeutic area: All drugs in Pain Management / Anesthesia
- Indication: Drugs for Postoperative pain management following shoulder surgery
- Indication: Drugs for Postoperative pain management following upper extremity surgery
- Also known as: Infilteration between popliteal artery and posterior capsule of the knee
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing