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NCT03954379
IPACK Study in Total Knee Arthroplasty Patients
Phase 4 trial testing Standard of Care (ACB, SA, peri-op pain management) in Knee Replacement Arthroplasty in 78 participants. Completed in 31 March 2021.
2 December 2020
Quick facts
| Lead sponsor | University Health Network, Toronto |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 78 |
| Start date | 24 October 2019 |
| Primary completion | 2 December 2020 |
| Estimated completion | 31 March 2021 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Standard of Care (ACB, SA, peri-op pain management) — full drug profile →
- IPACK and multi-modal analgesic regimen — full drug profile →
- Periarticular Local Anesthetic Infiltration
- IV Dexamethasone 8mg at the end of surgery as standard of care — full drug profile →
Conditions studied
- Knee Replacement Arthroplasty — all drugs for Knee Replacement Arthroplasty →
Sponsor
University Health Network, Toronto
Who can join
Adults 18 to 85, any sex, with Knee Replacement Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study proposes to compare current multimodal analgesic treatment for TKA with a new multimodal analgesic regimen to demonstrate decreased opioid requirement, time to rehabilitation, and time to reach hospital discharge.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT03954379
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Knee Replacement Arthroplasty
Currently open trials in the same condition.
- NCT06968143 — Investigating Patient Satisfaction With Smart Knee Implants · NA · recruiting
Other University Health Network, Toronto trials
Trials by the same sponsor.
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- NCT06836726 — Clinical Trial to Test Efficacy of Targeting Hypoxia Combined With ARSI After First-line ARSI Therapy for Castrate Resis · Phase 2 · not yet recruiting
- NCT07515651 — Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas · Phase 2 · not yet recruiting
- NCT07509450 — Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cel · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03954379 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Health Network, Toronto
- Last refreshed: 29 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03954379.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing