{"id":"ipack-and-multi-modal-analgesic-regimen","safety":{"commonSideEffects":[{"rate":null,"effect":"Nerve injury or neuropraxia"},{"rate":null,"effect":"Vascular puncture"},{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Hematoma"}]},"_chembl":{"chemblId":"CHEMBL1628401","moleculeType":"Small molecule","molecularWeight":"657.81"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"IPACK is a regional anesthesia technique that blocks multiple nerve pathways (interscalene, pectoral, axillary, and knee blocks) to provide localized pain control in the shoulder and upper extremity. When combined with a multi-modal analgesic regimen (typically including NSAIDs, acetaminophen, and other non-opioid agents), it provides comprehensive perioperative pain management that reduces reliance on opioid medications and improves recovery outcomes.","oneSentence":"IPACK (Interscalene block, Pecs block, Axillary block, and Knee block) combined with multi-modal analgesia delivers regional anesthesia and systemic pain relief to reduce postoperative pain and opioid consumption.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:40:57.519Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management following shoulder surgery"},{"name":"Postoperative pain management following upper extremity surgery"}]},"trialDetails":[{"nctId":"NCT07024043","phase":"PHASE1, PHASE2","title":"Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ain Shams University","startDate":"2025-03-03","conditions":"Efficacy of Drugs in Pain Management","enrollment":75},{"nctId":"NCT03954379","phase":"PHASE4","title":"IPACK Study in Total Knee Arthroplasty Patients","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2019-10-24","conditions":"Knee Replacement Arthroplasty","enrollment":78}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Infilteration between popliteal artery and posterior capsule of the knee"],"phase":"marketed","status":"active","brandName":"IPACK and multi-modal analgesic regimen","genericName":"IPACK and multi-modal analgesic regimen","companyName":"University Health Network, Toronto","companyId":"university-health-network-toronto","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IPACK (Interscalene block, Pecs block, Axillary block, and Knee block) combined with multi-modal analgesia delivers regional anesthesia and systemic pain relief to reduce postoperative pain and opioid consumption. Used for Postoperative pain management following shoulder surgery, Postoperative pain management following upper extremity surgery.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}