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intravenous sedation with propofol
Propofol acts as a GABA_A receptor agonist, enhancing the inhibitory effects of GABA in the brain.
Propofol acts as a GABA_A receptor agonist, enhancing the inhibitory effects of GABA in the brain. Used for Sedation for diagnostic and surgical procedures, Induction and maintenance of general anesthesia.
At a glance
| Generic name | intravenous sedation with propofol |
|---|---|
| Sponsor | University Hospital, Clermont-Ferrand |
| Drug class | GABA_A receptor agonist |
| Target | GABA_A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
This results in sedation and hypnosis, making it useful for inducing and maintaining anesthesia. Propofol's mechanism of action is complex and involves multiple sites of action, including the GABA_A receptor, which is the primary site of action.
Approved indications
- Sedation for diagnostic and surgical procedures
- Induction and maintenance of general anesthesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
Key clinical trials
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy (PHASE4)
- Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration (PHASE3)
- Inhaled Sedation in Critically Ill Patients (PHASE4)
- Reduction of Muscle Catabolism Through Brain Activation in Burn Patients (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
- Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium (PHASE4)
- Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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