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Infusion of Ropivacaine during 48 hours
Infusion of Ropivacaine during 48 hours is a Local anesthetic (amide class) Small molecule drug developed by University Hospital, Rouen. It is currently in Phase 3 development for Postoperative pain management via continuous peripheral nerve block or infiltration, Regional anesthesia for surgical procedures.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Postoperative pain management via continuous peripheral nerve block or infiltration, Regional anesthesia for surgical procedures.
At a glance
| Generic name | Infusion of Ropivacaine during 48 hours |
|---|---|
| Sponsor | University Hospital, Rouen |
| Drug class | Local anesthetic (amide class) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine reversibly inhibits sodium influx into nerve fibers, which stabilizes the neuronal membrane and prevents depolarization. This action blocks pain signal transmission along peripheral nerves. When infused continuously over 48 hours, it provides prolonged regional anesthesia or analgesia to a localized area.
Approved indications
- Postoperative pain management via continuous peripheral nerve block or infiltration
- Regional anesthesia for surgical procedures
Common side effects
- Systemic toxicity (CNS effects: dizziness, tinnitus, seizures)
- Cardiovascular effects (hypotension, bradycardia)
- Local site reactions (erythema, edema)
- Nausea
Key clinical trials
- Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery (NA)
- Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial) (NA)
- Administration of Ropivacaine by Bi-laterosternal Multiperforated Catheters Placed Before a Sternotomy for Cardiac Surgery (PHASE2)
- Analgesic Efficacy of Continuous Infusion of Local Anaesthetic Versus Single-shot Injection Interscalene Block (NA)
- Impact of Perioperative Analgesia in Prostatectomy Patients on Early Quality of Recovery (SPITALIDO) (NA)
- ESP Catheter Vs Single Shot ESP for Open Heart Surgery in Infants (NA)
- Efficacy of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery (PHASE3)
- The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Infusion of Ropivacaine during 48 hours CI brief — competitive landscape report
- Infusion of Ropivacaine during 48 hours updates RSS · CI watch RSS
- University Hospital, Rouen portfolio CI
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Related
- Drug class: All Local anesthetic (amide class) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University Hospital, Rouen — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Postoperative pain management via continuous peripheral nerve block or infiltration
- Indication: Drugs for Regional anesthesia for surgical procedures
- Compare: Infusion of Ropivacaine during 48 hours vs similar drugs
- Pricing: Infusion of Ropivacaine during 48 hours cost, discount & access