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i.v. sodium bicarbonate
Intravenous sodium bicarbonate raises blood pH and alkalinity to counteract metabolic acidosis and improve systemic acid-base balance.
Intravenous sodium bicarbonate raises blood pH and alkalinity to counteract metabolic acidosis and improve systemic acid-base balance. Used for Metabolic acidosis, Diabetic ketoacidosis, Renal tubular acidosis.
At a glance
| Generic name | i.v. sodium bicarbonate |
|---|---|
| Also known as | HCO3 |
| Sponsor | G. d'Annunzio University |
| Drug class | Buffer / alkalinizing agent |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Emergency Medicine |
| Phase | Phase 3 |
Mechanism of action
Sodium bicarbonate is a buffer that neutralizes excess hydrogen ions in the bloodstream, increasing serum pH and bicarbonate concentration. It is used to treat metabolic acidosis from various causes including renal failure, diabetic ketoacidosis, and drug overdoses. The alkalinizing effect can also enhance renal excretion of certain drugs and reduce hyperkalemia.
Approved indications
- Metabolic acidosis
- Diabetic ketoacidosis
- Renal tubular acidosis
- Drug overdose management (e.g., tricyclic antidepressants, aspirin)
Common side effects
- Hypernatremia
- Hypokalemia
- Metabolic alkalosis
- Phlebitis at injection site
- Fluid overload
Key clinical trials
- A First-in-Human Study to Assess the Safety and Tolerability of PDNO (PHASE1)
- PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization (PHASE3)
- RenalGuard System and Contrast Media (PHASE3)
- N-GAL Allows Intensive Treatment of Contrast Induced Nephropathy (PHASE4)
- PROVOCATION Trial - PROphylactic intraVenOus Hydration for Contrast Agent Toxicity PreventION (PHASE2, PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- i.v. sodium bicarbonate CI brief — competitive landscape report
- i.v. sodium bicarbonate updates RSS · CI watch RSS
- G. d'Annunzio University portfolio CI